Feasibility of high-dose tadalafil and effects on insulin resistance in well-controlled patients with type 2 diabetes (MAKROTAD): a single-centre, double-blind, randomised, placebo-controlled, cross-over phase 2 trial

BACKGROUND: Phosphodiesterase-5 inhibitors exert positive vascular and metabolic effects in type 2 diabetes (T2D), but the effect on insulin resistance in T2D is unclear. METHODS: This randomised, double blind, placebo-controlled, two-period crossover trial was conducted at Sahlgrenska University Ho...

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Detalles Bibliográficos
Autores principales: Fryk, Emanuel, Rodrigues Silva, Vagner Ramon, Bauzá-Thorbrügge, Marco, Schmelz, Martin, Gan, Li-Ming, Strindberg, Lena, Jansson, Per-Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225663/
https://www.ncbi.nlm.nih.gov/pubmed/37256099
http://dx.doi.org/10.1016/j.eclinm.2023.101985

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