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Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis

OBJECTIVE: Non-invasive disease indicators are currently limited and need further research due to the increased non-alcoholic fatty liver disease (NAFLD) prevalence worldwide. The serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has been recognized as a novel inflammatory and meta...

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Autores principales: Xie, Yilian, Huang, Kai, Zhang, Xiangyu, Wu, Zhouxiao, Wu, Yiyi, Chu, Jinguo, Kong, Weiliang, Qian, Guoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225665/
https://www.ncbi.nlm.nih.gov/pubmed/37256087
http://dx.doi.org/10.3389/fmed.2023.1164096
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author Xie, Yilian
Huang, Kai
Zhang, Xiangyu
Wu, Zhouxiao
Wu, Yiyi
Chu, Jinguo
Kong, Weiliang
Qian, Guoqing
author_facet Xie, Yilian
Huang, Kai
Zhang, Xiangyu
Wu, Zhouxiao
Wu, Yiyi
Chu, Jinguo
Kong, Weiliang
Qian, Guoqing
author_sort Xie, Yilian
collection PubMed
description OBJECTIVE: Non-invasive disease indicators are currently limited and need further research due to the increased non-alcoholic fatty liver disease (NAFLD) prevalence worldwide. The serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has been recognized as a novel inflammatory and metabolic marker. Herein, we explored the correlation between UHR and the risk of NAFLD in-depth. METHODS: A total of 3,766 participants were included in our survey, and the National Health and Nutrition Examination Survey (NHANES) 2017–2018 cycle provided the cross-sectional study population. Weighted multivariable logistic regression and multivariate linear regression analyses were performed to assess the association between the UHR and the odds of NAFLD and liver steatosis and fibrosis severity, respectively. Moreover, we explored the non-linear relationship between the UHR and NAFLD by the generalized additive model. RESULTS: NAFLD probabilities were statistically demonstrated to be positively correlated with the UHR (OR = 1.331 per SD increase, 95% CI: 1.100, 1.611). The positive connection of the UHR with NAFLD risk persisted significantly in female subjects but not in male subjects in subgroup analyses stratified by gender. The non-linear relationship analysis demonstrated that a UHR between ~20 and 30% suggested a saturation effect of NAFLD risk. Furthermore, a dramatically positive correlation was found between the UHR and hepatic steatosis severity but not fibrosis. Finally, the receiver operating characteristic analysis suggested that UHR had a better predictive value for NAFLD than either serum uric acid (sUA) or high-density lipoprotein cholesterol (HDL) alone [UHR (area under curve): 0.6910; 95% CI: 0.6737–0.7083; P < 0.0001]. CONCLUSION: Our investigation revealed that the elevated UHR level was independently related to an increased NAFLD risk and the severity of liver steatosis in American individuals. The correlation differed according to sex. This non-invasive indicator may enhance the capacity to predict the onset of NAFLD and may uncover alternative therapeutic interventional targets.
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spelling pubmed-102256652023-05-30 Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis Xie, Yilian Huang, Kai Zhang, Xiangyu Wu, Zhouxiao Wu, Yiyi Chu, Jinguo Kong, Weiliang Qian, Guoqing Front Med (Lausanne) Medicine OBJECTIVE: Non-invasive disease indicators are currently limited and need further research due to the increased non-alcoholic fatty liver disease (NAFLD) prevalence worldwide. The serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has been recognized as a novel inflammatory and metabolic marker. Herein, we explored the correlation between UHR and the risk of NAFLD in-depth. METHODS: A total of 3,766 participants were included in our survey, and the National Health and Nutrition Examination Survey (NHANES) 2017–2018 cycle provided the cross-sectional study population. Weighted multivariable logistic regression and multivariate linear regression analyses were performed to assess the association between the UHR and the odds of NAFLD and liver steatosis and fibrosis severity, respectively. Moreover, we explored the non-linear relationship between the UHR and NAFLD by the generalized additive model. RESULTS: NAFLD probabilities were statistically demonstrated to be positively correlated with the UHR (OR = 1.331 per SD increase, 95% CI: 1.100, 1.611). The positive connection of the UHR with NAFLD risk persisted significantly in female subjects but not in male subjects in subgroup analyses stratified by gender. The non-linear relationship analysis demonstrated that a UHR between ~20 and 30% suggested a saturation effect of NAFLD risk. Furthermore, a dramatically positive correlation was found between the UHR and hepatic steatosis severity but not fibrosis. Finally, the receiver operating characteristic analysis suggested that UHR had a better predictive value for NAFLD than either serum uric acid (sUA) or high-density lipoprotein cholesterol (HDL) alone [UHR (area under curve): 0.6910; 95% CI: 0.6737–0.7083; P < 0.0001]. CONCLUSION: Our investigation revealed that the elevated UHR level was independently related to an increased NAFLD risk and the severity of liver steatosis in American individuals. The correlation differed according to sex. This non-invasive indicator may enhance the capacity to predict the onset of NAFLD and may uncover alternative therapeutic interventional targets. Frontiers Media S.A. 2023-05-15 /pmc/articles/PMC10225665/ /pubmed/37256087 http://dx.doi.org/10.3389/fmed.2023.1164096 Text en Copyright © 2023 Xie, Huang, Zhang, Wu, Wu, Chu, Kong and Qian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Xie, Yilian
Huang, Kai
Zhang, Xiangyu
Wu, Zhouxiao
Wu, Yiyi
Chu, Jinguo
Kong, Weiliang
Qian, Guoqing
Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis
title Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis
title_full Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis
title_fullStr Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis
title_full_unstemmed Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis
title_short Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis
title_sort association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in american adults: a population-based analysis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225665/
https://www.ncbi.nlm.nih.gov/pubmed/37256087
http://dx.doi.org/10.3389/fmed.2023.1164096
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