High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre, randomised, double-blinded, placebo-controlled phase 2 trial

BACKGROUND: Functionally impaired variants of COQ2, encoding an enzyme in biosynthesis of coenzyme Q10 (CoQ10), were found in familial multiple system atrophy (MSA) and V393A in COQ2 is associated with sporadic MSA. Furthermore, reduced levels of CoQ10 have been demonstrated in MSA patients. METHODS...

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Detalles Bibliográficos
Autores principales: Mitsui, Jun, Matsukawa, Takashi, Uemura, Yukari, Kawahara, Takuya, Chikada, Ayaka, Porto, Kristine Joyce L., Naruse, Hiroya, Tanaka, Masaki, Ishiura, Hiroyuki, Toda, Tatsushi, Kuzuyama, Haruko, Hirano, Mari, Wada, Ikue, Ga, Toshio, Moritoyo, Takashi, Takahashi, Yuji, Mizusawa, Hidehiro, Ishikawa, Kinya, Yokota, Takanori, Kuwabara, Satoshi, Sawamoto, Nobukatsu, Takahashi, Ryosuke, Abe, Koji, Ishihara, Tomohiko, Onodera, Osamu, Matsuse, Dai, Yamasaki, Ryo, Kira, Jun-Ichi, Katsuno, Masahisa, Hanajima, Ritsuko, Ogata, Katsuhisa, Takashima, Hiroshi, Matsushima, Masaaki, Yabe, Ichiro, Sasaki, Hidenao, Tsuji, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225719/
https://www.ncbi.nlm.nih.gov/pubmed/37256098
http://dx.doi.org/10.1016/j.eclinm.2023.101920

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