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White matter and neurochemical mechanisms underlying age-related differences in motor processing speed
Aging is associated with changes in the central nervous system and leads to reduced life quality. Here, we investigated the age-related differences in the CNS underlying motor performance deficits using magnetic resonance spectroscopy and diffusion MRI. MRS measured N-acetyl aspartate (NAA), choline...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225899/ https://www.ncbi.nlm.nih.gov/pubmed/37255665 http://dx.doi.org/10.1016/j.isci.2023.106794 |
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author | Rasooli, Amirhossein Adab, Hamed Zivari Van Ruitenbeek, Peter Weerasekera, Akila Chalavi, Sima Cuypers, Koen Levin, Oron Dhollander, Thijs Peeters, Ronald Sunaert, Stefan Mantini, Dante Swinnen, Stephan P. |
author_facet | Rasooli, Amirhossein Adab, Hamed Zivari Van Ruitenbeek, Peter Weerasekera, Akila Chalavi, Sima Cuypers, Koen Levin, Oron Dhollander, Thijs Peeters, Ronald Sunaert, Stefan Mantini, Dante Swinnen, Stephan P. |
author_sort | Rasooli, Amirhossein |
collection | PubMed |
description | Aging is associated with changes in the central nervous system and leads to reduced life quality. Here, we investigated the age-related differences in the CNS underlying motor performance deficits using magnetic resonance spectroscopy and diffusion MRI. MRS measured N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr) concentrations in the sensorimotor and occipital cortex, whereas dMRI quantified apparent fiber density (FD) in the same voxels to evaluate white matter microstructural organization. We found that aging was associated with increased reaction time and reduced FD and NAA concentration in the sensorimotor voxel. Both FD and NAA mediated the association between age and reaction time. The NAA concentration was found to mediate the association between age and FD in the sensorimotor voxel. We propose that the age-related decrease in NAA concentration may result in reduced axonal fiber density in the sensorimotor cortex which may ultimately account for the response slowness of older participants. |
format | Online Article Text |
id | pubmed-10225899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102258992023-05-30 White matter and neurochemical mechanisms underlying age-related differences in motor processing speed Rasooli, Amirhossein Adab, Hamed Zivari Van Ruitenbeek, Peter Weerasekera, Akila Chalavi, Sima Cuypers, Koen Levin, Oron Dhollander, Thijs Peeters, Ronald Sunaert, Stefan Mantini, Dante Swinnen, Stephan P. iScience Article Aging is associated with changes in the central nervous system and leads to reduced life quality. Here, we investigated the age-related differences in the CNS underlying motor performance deficits using magnetic resonance spectroscopy and diffusion MRI. MRS measured N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr) concentrations in the sensorimotor and occipital cortex, whereas dMRI quantified apparent fiber density (FD) in the same voxels to evaluate white matter microstructural organization. We found that aging was associated with increased reaction time and reduced FD and NAA concentration in the sensorimotor voxel. Both FD and NAA mediated the association between age and reaction time. The NAA concentration was found to mediate the association between age and FD in the sensorimotor voxel. We propose that the age-related decrease in NAA concentration may result in reduced axonal fiber density in the sensorimotor cortex which may ultimately account for the response slowness of older participants. Elsevier 2023-05-03 /pmc/articles/PMC10225899/ /pubmed/37255665 http://dx.doi.org/10.1016/j.isci.2023.106794 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rasooli, Amirhossein Adab, Hamed Zivari Van Ruitenbeek, Peter Weerasekera, Akila Chalavi, Sima Cuypers, Koen Levin, Oron Dhollander, Thijs Peeters, Ronald Sunaert, Stefan Mantini, Dante Swinnen, Stephan P. White matter and neurochemical mechanisms underlying age-related differences in motor processing speed |
title | White matter and neurochemical mechanisms underlying age-related differences in motor processing speed |
title_full | White matter and neurochemical mechanisms underlying age-related differences in motor processing speed |
title_fullStr | White matter and neurochemical mechanisms underlying age-related differences in motor processing speed |
title_full_unstemmed | White matter and neurochemical mechanisms underlying age-related differences in motor processing speed |
title_short | White matter and neurochemical mechanisms underlying age-related differences in motor processing speed |
title_sort | white matter and neurochemical mechanisms underlying age-related differences in motor processing speed |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225899/ https://www.ncbi.nlm.nih.gov/pubmed/37255665 http://dx.doi.org/10.1016/j.isci.2023.106794 |
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