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Dysfunction of the neurovascular unit in brain aging

An emerging concept termed the neurovascular unit (NVU) underlines neurovascular coupling. It has been reported that NVU impairment can result in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Aging is a complex and irreversible process caused by programme...

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Detalles Bibliográficos
Autores principales: Liu, Shu, Yang, Xu, Chen, Fei, Cai, Zhiyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226086/
https://www.ncbi.nlm.nih.gov/pubmed/37198158
http://dx.doi.org/10.7555/JBR.36.20220105
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author Liu, Shu
Yang, Xu
Chen, Fei
Cai, Zhiyou
author_facet Liu, Shu
Yang, Xu
Chen, Fei
Cai, Zhiyou
author_sort Liu, Shu
collection PubMed
description An emerging concept termed the neurovascular unit (NVU) underlines neurovascular coupling. It has been reported that NVU impairment can result in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Aging is a complex and irreversible process caused by programmed and damage-related factors. Loss of biological functions and increased susceptibility to additional neurodegenerative diseases are major characteristics of aging. In this review, we describe the basics of the NVU and discuss the effect of aging on NVU basics. Furthermore, we summarize the mechanisms that increase NVU susceptibility to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Finally, we discuss new treatments for neurodegenerative diseases and methods of maintaining an intact NVU that may delay or diminish aging.
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spelling pubmed-102260862023-05-30 Dysfunction of the neurovascular unit in brain aging Liu, Shu Yang, Xu Chen, Fei Cai, Zhiyou J Biomed Res Review Article An emerging concept termed the neurovascular unit (NVU) underlines neurovascular coupling. It has been reported that NVU impairment can result in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Aging is a complex and irreversible process caused by programmed and damage-related factors. Loss of biological functions and increased susceptibility to additional neurodegenerative diseases are major characteristics of aging. In this review, we describe the basics of the NVU and discuss the effect of aging on NVU basics. Furthermore, we summarize the mechanisms that increase NVU susceptibility to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Finally, we discuss new treatments for neurodegenerative diseases and methods of maintaining an intact NVU that may delay or diminish aging. Editorial Department of Journal of Biomedical Research 2023-05 2023-04-15 /pmc/articles/PMC10226086/ /pubmed/37198158 http://dx.doi.org/10.7555/JBR.36.20220105 Text en Copyright and License information: Journal of Biomedical Research, CAS Springer-Verlag Berlin Heidelberg 2023 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Liu, Shu
Yang, Xu
Chen, Fei
Cai, Zhiyou
Dysfunction of the neurovascular unit in brain aging
title Dysfunction of the neurovascular unit in brain aging
title_full Dysfunction of the neurovascular unit in brain aging
title_fullStr Dysfunction of the neurovascular unit in brain aging
title_full_unstemmed Dysfunction of the neurovascular unit in brain aging
title_short Dysfunction of the neurovascular unit in brain aging
title_sort dysfunction of the neurovascular unit in brain aging
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226086/
https://www.ncbi.nlm.nih.gov/pubmed/37198158
http://dx.doi.org/10.7555/JBR.36.20220105
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