Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

[Image: see text] Purine nucleoside phosphorylase (PNP) is a well-known molecular target with potential therapeutic applications in the treatment of T-cell malignancies and/or bacterial/parasitic infections. Here, we report the design, development of synthetic methodology, and biological evaluation...

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Detalles Bibliográficos
Autores principales: Skácel, Jan, Djukic, Stefan, Baszczyňski, Ondřej, Kalčic, Filip, Bílek, Tadeáš, Chalupský, Karel, Kozák, Jaroslav, Dvořáková, Alexandra, Tloušt’ová, Eva, Král’ová, Zuzana, Šmídková, Markéta, Voldřich, Jan, Rumlová, Michaela, Pachl, Petr, Brynda, Jiří, Vučková, Tereza, Fábry, Milan, Snášel, Jan, Pichová, Iva, Řezáčová, Pavlína, Mertlíková-Kaiserová, Helena, Janeba, Zlatko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226123/
https://www.ncbi.nlm.nih.gov/pubmed/37134237
http://dx.doi.org/10.1021/acs.jmedchem.2c02097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226123/
https://www.ncbi.nlm.nih.gov/pubmed/37134237
http://dx.doi.org/10.1021/acs.jmedchem.2c02097

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