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Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
[Image: see text] Purine nucleoside phosphorylase (PNP) is a well-known molecular target with potential therapeutic applications in the treatment of T-cell malignancies and/or bacterial/parasitic infections. Here, we report the design, development of synthetic methodology, and biological evaluation...
Autores principales: | Skácel, Jan, Djukic, Stefan, Baszczyňski, Ondřej, Kalčic, Filip, Bílek, Tadeáš, Chalupský, Karel, Kozák, Jaroslav, Dvořáková, Alexandra, Tloušt’ová, Eva, Král’ová, Zuzana, Šmídková, Markéta, Voldřich, Jan, Rumlová, Michaela, Pachl, Petr, Brynda, Jiří, Vučková, Tereza, Fábry, Milan, Snášel, Jan, Pichová, Iva, Řezáčová, Pavlína, Mertlíková-Kaiserová, Helena, Janeba, Zlatko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226123/ https://www.ncbi.nlm.nih.gov/pubmed/37134237 http://dx.doi.org/10.1021/acs.jmedchem.2c02097 |
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