First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8

[Image: see text] KAT8 is a lysine acetyltransferase primarily catalyzing the acetylation of Lys16 of histone H4 (H4K16). KAT8 dysregulation is linked to the development and metastatization of many cancer types, including non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML). Few KAT8...

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Autores principales: Fiorentino, Francesco, Sementilli, Sara, Menna, Martina, Turrisi, Federica, Tomassi, Stefano, Pellegrini, Francesca Romana, Iuzzolino, Angela, D’Acunzo, Francesca, Feoli, Alessandra, Wapenaar, Hannah, Taraglio, Sophie, Fraschetti, Caterina, Del Bufalo, Donatella, Sbardella, Gianluca, Dekker, Frank J., Paiardini, Alessandro, Trisciuoglio, Daniela, Mai, Antonello, Rotili, Dante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226132/
https://www.ncbi.nlm.nih.gov/pubmed/37155735
http://dx.doi.org/10.1021/acs.jmedchem.2c01937

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