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Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis
BACKGROUND: Psychological stress has been proved to be a risk factor for exacerbation for ulcerative colitis (UC). However, traditional approaches of quantifying psychological stress using psychological scales are time-consuming and the results may not be comparable among patients with different edu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226224/ https://www.ncbi.nlm.nih.gov/pubmed/37248493 http://dx.doi.org/10.1186/s12876-023-02823-2 |
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author | Guo, Jianan Chen, Wenguo Zhu, Huatuo Chen, Hongtan Teng, Xiaodong Xu, Guoqiang |
author_facet | Guo, Jianan Chen, Wenguo Zhu, Huatuo Chen, Hongtan Teng, Xiaodong Xu, Guoqiang |
author_sort | Guo, Jianan |
collection | PubMed |
description | BACKGROUND: Psychological stress has been proved to be a risk factor for exacerbation for ulcerative colitis (UC). However, traditional approaches of quantifying psychological stress using psychological scales are time-consuming and the results may not be comparable among patients with different educational levels and cultural backgrounds. Alternatively, heart rate variability (HRV) is an indicator for psychological stress and not biased by educational and cultural backgrounds. AIMS: In this study, we try to explore the relationship between psychological stress and UC by analyzing the effect of ultra-short-term HRV on mucosal and histological remission status of UC. METHODS: This is a retrospective case–control study on UC inpatients from 2018 through 2020. Ultra-short-term HRV were calculated using baseline electrocardiography. Patients were divided intocase and control groups according to their Mayo endoscopic scores or histological Geboes scores. Three variables of ultra-short-term HRV (the standard deviation of normal to normal R-R intervals (SDNN), the standard deviation of successive differences between adjacent normal to normal R-R intervals (SDSD), the root mean square of successive differences of normal to normal R-R intervals (RMSSD)) were compared between different groups. And for those variables with significant differences, we built univariate and multivariate logistic regressions to depict the relationship between HRV variables and remission status of UC. RESULTS: All three HRV variables showed significant differences between the mucosal groups. However, none of them showed significant difference between the histological groups. In further logistic regression analyses, smaller RMSSD can predict severe mucosal healing status (OR = 5.21). CONCLUSIONS: Lower ultra-short-term HRV (i.e. smaller RMSSD) is shown to positively correlate with worse mucosal healing status. However, ultra-short-term HRV cannot predict histological healing status according to our data. |
format | Online Article Text |
id | pubmed-10226224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102262242023-05-30 Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis Guo, Jianan Chen, Wenguo Zhu, Huatuo Chen, Hongtan Teng, Xiaodong Xu, Guoqiang BMC Gastroenterol Research Article BACKGROUND: Psychological stress has been proved to be a risk factor for exacerbation for ulcerative colitis (UC). However, traditional approaches of quantifying psychological stress using psychological scales are time-consuming and the results may not be comparable among patients with different educational levels and cultural backgrounds. Alternatively, heart rate variability (HRV) is an indicator for psychological stress and not biased by educational and cultural backgrounds. AIMS: In this study, we try to explore the relationship between psychological stress and UC by analyzing the effect of ultra-short-term HRV on mucosal and histological remission status of UC. METHODS: This is a retrospective case–control study on UC inpatients from 2018 through 2020. Ultra-short-term HRV were calculated using baseline electrocardiography. Patients were divided intocase and control groups according to their Mayo endoscopic scores or histological Geboes scores. Three variables of ultra-short-term HRV (the standard deviation of normal to normal R-R intervals (SDNN), the standard deviation of successive differences between adjacent normal to normal R-R intervals (SDSD), the root mean square of successive differences of normal to normal R-R intervals (RMSSD)) were compared between different groups. And for those variables with significant differences, we built univariate and multivariate logistic regressions to depict the relationship between HRV variables and remission status of UC. RESULTS: All three HRV variables showed significant differences between the mucosal groups. However, none of them showed significant difference between the histological groups. In further logistic regression analyses, smaller RMSSD can predict severe mucosal healing status (OR = 5.21). CONCLUSIONS: Lower ultra-short-term HRV (i.e. smaller RMSSD) is shown to positively correlate with worse mucosal healing status. However, ultra-short-term HRV cannot predict histological healing status according to our data. BioMed Central 2023-05-29 /pmc/articles/PMC10226224/ /pubmed/37248493 http://dx.doi.org/10.1186/s12876-023-02823-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Guo, Jianan Chen, Wenguo Zhu, Huatuo Chen, Hongtan Teng, Xiaodong Xu, Guoqiang Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis |
title | Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis |
title_full | Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis |
title_fullStr | Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis |
title_full_unstemmed | Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis |
title_short | Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis |
title_sort | lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226224/ https://www.ncbi.nlm.nih.gov/pubmed/37248493 http://dx.doi.org/10.1186/s12876-023-02823-2 |
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