Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection

This is a case report of a previously healthy female patient with complement-mediated thrombotic microangiopathy (TMA) caused by a systemic cytomegalovirus infection that was successfully treated with plasmapheresis, steroids, and parenteral valganciclovir. Complement-mediated TMA is the result of v...

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Autores principales: Shabir, Sadia, Spencer, Caleb T, Tabassum, Arooj, Chandra, Arjun, Sayeh, Wasef, Safi, Fadi, Ud din, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226295/
https://www.ncbi.nlm.nih.gov/pubmed/37232266
http://dx.doi.org/10.1177/23247096231172467
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author Shabir, Sadia
Spencer, Caleb T
Tabassum, Arooj
Chandra, Arjun
Sayeh, Wasef
Safi, Fadi
Ud din, Shahab
author_facet Shabir, Sadia
Spencer, Caleb T
Tabassum, Arooj
Chandra, Arjun
Sayeh, Wasef
Safi, Fadi
Ud din, Shahab
author_sort Shabir, Sadia
collection PubMed
description This is a case report of a previously healthy female patient with complement-mediated thrombotic microangiopathy (TMA) caused by a systemic cytomegalovirus infection that was successfully treated with plasmapheresis, steroids, and parenteral valganciclovir. Complement-mediated TMA is the result of various genetic mutations leading to complement abnormalities with overactivation of alternate complement pathway in response to a triggering infection. She also had splenic rupture without splenomegaly and was managed successfully without splenectomy.
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spelling pubmed-102262952023-05-30 Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection Shabir, Sadia Spencer, Caleb T Tabassum, Arooj Chandra, Arjun Sayeh, Wasef Safi, Fadi Ud din, Shahab J Investig Med High Impact Case Rep Case Report This is a case report of a previously healthy female patient with complement-mediated thrombotic microangiopathy (TMA) caused by a systemic cytomegalovirus infection that was successfully treated with plasmapheresis, steroids, and parenteral valganciclovir. Complement-mediated TMA is the result of various genetic mutations leading to complement abnormalities with overactivation of alternate complement pathway in response to a triggering infection. She also had splenic rupture without splenomegaly and was managed successfully without splenectomy. SAGE Publications 2023-05-26 /pmc/articles/PMC10226295/ /pubmed/37232266 http://dx.doi.org/10.1177/23247096231172467 Text en © 2023 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Shabir, Sadia
Spencer, Caleb T
Tabassum, Arooj
Chandra, Arjun
Sayeh, Wasef
Safi, Fadi
Ud din, Shahab
Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection
title Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection
title_full Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection
title_fullStr Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection
title_full_unstemmed Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection
title_short Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection
title_sort complement-mediated thrombotic microangiopathy and spontaneous splenic rupture associated with cytomegalovirus infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226295/
https://www.ncbi.nlm.nih.gov/pubmed/37232266
http://dx.doi.org/10.1177/23247096231172467
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