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Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler
Cushing’s syndrome is a rare disease in the paediatric age group. Adrenocortical carcinomas (ACC) constitute the most common cause of Cushing’s syndrome between 1 and 5 years of age. Often, adrenocortical carcinomas co-secrete other hormones such as androgens (testosterone), deoxy-corticosterone (DO...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226367/ https://www.ncbi.nlm.nih.gov/pubmed/35193331 http://dx.doi.org/10.5114/pedm.2021.109122 |
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author | Boro, Hiya Kubihal, Suraj Dutta, Rimlee Kubihal, Vijay Alam, Sarah Tandon, Nikhil |
author_facet | Boro, Hiya Kubihal, Suraj Dutta, Rimlee Kubihal, Vijay Alam, Sarah Tandon, Nikhil |
author_sort | Boro, Hiya |
collection | PubMed |
description | Cushing’s syndrome is a rare disease in the paediatric age group. Adrenocortical carcinomas (ACC) constitute the most common cause of Cushing’s syndrome between 1 and 5 years of age. Often, adrenocortical carcinomas co-secrete other hormones such as androgens (testosterone), deoxy-corticosterone (DOCA), or 17-hydroxy-progesterone [17(OH)P] in addition to cortisol. This may manifest with symptoms and signs of precocious puberty along with Cushing’s syndrome. It is rare for a benign adrenocortical adenoma to co-secrete androgens and other hormones in addition to cortisol. Differentiation between adenoma and carcinoma is difficult in all aspects: clinical, radiological, and histopathological. Here, we describe the case of a 2.5-year-old male child who presented with Cushing’s syndrome and virilization. Although we suspected ACC clinically, the radiological and histopathological findings were suggestive of benign adrenocortical adenoma. Our case represents the diagnostic challenge that exists in paediatric adrenocortical tumours. |
format | Online Article Text |
id | pubmed-10226367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-102263672023-06-05 Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler Boro, Hiya Kubihal, Suraj Dutta, Rimlee Kubihal, Vijay Alam, Sarah Tandon, Nikhil Pediatr Endocrinol Diabetes Metab Case report | Opis przypadku Cushing’s syndrome is a rare disease in the paediatric age group. Adrenocortical carcinomas (ACC) constitute the most common cause of Cushing’s syndrome between 1 and 5 years of age. Often, adrenocortical carcinomas co-secrete other hormones such as androgens (testosterone), deoxy-corticosterone (DOCA), or 17-hydroxy-progesterone [17(OH)P] in addition to cortisol. This may manifest with symptoms and signs of precocious puberty along with Cushing’s syndrome. It is rare for a benign adrenocortical adenoma to co-secrete androgens and other hormones in addition to cortisol. Differentiation between adenoma and carcinoma is difficult in all aspects: clinical, radiological, and histopathological. Here, we describe the case of a 2.5-year-old male child who presented with Cushing’s syndrome and virilization. Although we suspected ACC clinically, the radiological and histopathological findings were suggestive of benign adrenocortical adenoma. Our case represents the diagnostic challenge that exists in paediatric adrenocortical tumours. Termedia Publishing House 2022-02-21 2022-03 /pmc/articles/PMC10226367/ /pubmed/35193331 http://dx.doi.org/10.5114/pedm.2021.109122 Text en Copyright © Polish Society of Pediatric Endocrinology and Diabetes https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), allowing third parties to download and share its works but not commercially purposes or to create derivative works. |
spellingShingle | Case report | Opis przypadku Boro, Hiya Kubihal, Suraj Dutta, Rimlee Kubihal, Vijay Alam, Sarah Tandon, Nikhil Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler |
title | Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler |
title_full | Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler |
title_fullStr | Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler |
title_full_unstemmed | Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler |
title_short | Adrenocortical adenoma manifesting as Cushing’s syndrome and pseudo-precocious puberty in a toddler |
title_sort | adrenocortical adenoma manifesting as cushing’s syndrome and pseudo-precocious puberty in a toddler |
topic | Case report | Opis przypadku |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226367/ https://www.ncbi.nlm.nih.gov/pubmed/35193331 http://dx.doi.org/10.5114/pedm.2021.109122 |
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