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Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism
The SARS-CoV-2 virus is primarily transmitted through direct or indirect contact with the mucous membranes of the mouth and nostrils. The presence of SARS-CoV-2 in sputum with a high viral load suggested that maintaining good oral hygiene could be critical in limiting COVID-19 disease. Brushing the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226441/ https://www.ncbi.nlm.nih.gov/pubmed/37363087 http://dx.doi.org/10.1007/s42398-023-00279-4 |
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author | Akhter, Yusuf Rastogi, Shubham Kaithwas, Gaurav |
author_facet | Akhter, Yusuf Rastogi, Shubham Kaithwas, Gaurav |
author_sort | Akhter, Yusuf |
collection | PubMed |
description | The SARS-CoV-2 virus is primarily transmitted through direct or indirect contact with the mucous membranes of the mouth and nostrils. The presence of SARS-CoV-2 in sputum with a high viral load suggested that maintaining good oral hygiene could be critical in limiting COVID-19 disease. Brushing the teeth frequently and regularly with widely available amphiphilic detergent, sodium lauryl sulfate (SLS)-based toothpastes could help in preventing the spread of SARS-CoV-2. We proposed a community survey-based methodology followed by an in vitro biochemical strategy to test the virucidal potentiality of SLS, an amphiphilic detergent found in these toothpastes. Through biomolecular structure and docking analysis using models of spike protein and SLS, we showed a possible molecular mechanism of action for SLS-enabled viral particle inactivation. |
format | Online Article Text |
id | pubmed-10226441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-102264412023-05-30 Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism Akhter, Yusuf Rastogi, Shubham Kaithwas, Gaurav Environ Sustain (Singap) Scientific Opinion The SARS-CoV-2 virus is primarily transmitted through direct or indirect contact with the mucous membranes of the mouth and nostrils. The presence of SARS-CoV-2 in sputum with a high viral load suggested that maintaining good oral hygiene could be critical in limiting COVID-19 disease. Brushing the teeth frequently and regularly with widely available amphiphilic detergent, sodium lauryl sulfate (SLS)-based toothpastes could help in preventing the spread of SARS-CoV-2. We proposed a community survey-based methodology followed by an in vitro biochemical strategy to test the virucidal potentiality of SLS, an amphiphilic detergent found in these toothpastes. Through biomolecular structure and docking analysis using models of spike protein and SLS, we showed a possible molecular mechanism of action for SLS-enabled viral particle inactivation. Springer Nature Singapore 2023-05-29 /pmc/articles/PMC10226441/ /pubmed/37363087 http://dx.doi.org/10.1007/s42398-023-00279-4 Text en © The Author(s) under exclusive licence to Society for Environmental Sustainability 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Scientific Opinion Akhter, Yusuf Rastogi, Shubham Kaithwas, Gaurav Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism |
title | Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism |
title_full | Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism |
title_fullStr | Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism |
title_full_unstemmed | Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism |
title_short | Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism |
title_sort | frequent brushing of teeth inhibits the dissemination of the sars-cov-2: the biochemical mechanism |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226441/ https://www.ncbi.nlm.nih.gov/pubmed/37363087 http://dx.doi.org/10.1007/s42398-023-00279-4 |
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