Cargando…

Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism

The SARS-CoV-2 virus is primarily transmitted through direct or indirect contact with the mucous membranes of the mouth and nostrils. The presence of SARS-CoV-2 in sputum with a high viral load suggested that maintaining good oral hygiene could be critical in limiting COVID-19 disease. Brushing the...

Descripción completa

Detalles Bibliográficos
Autores principales: Akhter, Yusuf, Rastogi, Shubham, Kaithwas, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226441/
https://www.ncbi.nlm.nih.gov/pubmed/37363087
http://dx.doi.org/10.1007/s42398-023-00279-4
_version_ 1785050575690268672
author Akhter, Yusuf
Rastogi, Shubham
Kaithwas, Gaurav
author_facet Akhter, Yusuf
Rastogi, Shubham
Kaithwas, Gaurav
author_sort Akhter, Yusuf
collection PubMed
description The SARS-CoV-2 virus is primarily transmitted through direct or indirect contact with the mucous membranes of the mouth and nostrils. The presence of SARS-CoV-2 in sputum with a high viral load suggested that maintaining good oral hygiene could be critical in limiting COVID-19 disease. Brushing the teeth frequently and regularly with widely available amphiphilic detergent, sodium lauryl sulfate (SLS)-based toothpastes could help in preventing the spread of SARS-CoV-2. We proposed a community survey-based methodology followed by an in vitro biochemical strategy to test the virucidal potentiality of SLS, an amphiphilic detergent found in these toothpastes. Through biomolecular structure and docking analysis using models of spike protein and SLS, we showed a possible molecular mechanism of action for SLS-enabled viral particle inactivation.
format Online
Article
Text
id pubmed-10226441
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Nature Singapore
record_format MEDLINE/PubMed
spelling pubmed-102264412023-05-30 Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism Akhter, Yusuf Rastogi, Shubham Kaithwas, Gaurav Environ Sustain (Singap) Scientific Opinion The SARS-CoV-2 virus is primarily transmitted through direct or indirect contact with the mucous membranes of the mouth and nostrils. The presence of SARS-CoV-2 in sputum with a high viral load suggested that maintaining good oral hygiene could be critical in limiting COVID-19 disease. Brushing the teeth frequently and regularly with widely available amphiphilic detergent, sodium lauryl sulfate (SLS)-based toothpastes could help in preventing the spread of SARS-CoV-2. We proposed a community survey-based methodology followed by an in vitro biochemical strategy to test the virucidal potentiality of SLS, an amphiphilic detergent found in these toothpastes. Through biomolecular structure and docking analysis using models of spike protein and SLS, we showed a possible molecular mechanism of action for SLS-enabled viral particle inactivation. Springer Nature Singapore 2023-05-29 /pmc/articles/PMC10226441/ /pubmed/37363087 http://dx.doi.org/10.1007/s42398-023-00279-4 Text en © The Author(s) under exclusive licence to Society for Environmental Sustainability 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Scientific Opinion
Akhter, Yusuf
Rastogi, Shubham
Kaithwas, Gaurav
Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism
title Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism
title_full Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism
title_fullStr Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism
title_full_unstemmed Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism
title_short Frequent brushing of teeth inhibits the dissemination of the SARS-CoV-2: the biochemical mechanism
title_sort frequent brushing of teeth inhibits the dissemination of the sars-cov-2: the biochemical mechanism
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226441/
https://www.ncbi.nlm.nih.gov/pubmed/37363087
http://dx.doi.org/10.1007/s42398-023-00279-4
work_keys_str_mv AT akhteryusuf frequentbrushingofteethinhibitsthedisseminationofthesarscov2thebiochemicalmechanism
AT rastogishubham frequentbrushingofteethinhibitsthedisseminationofthesarscov2thebiochemicalmechanism
AT kaithwasgaurav frequentbrushingofteethinhibitsthedisseminationofthesarscov2thebiochemicalmechanism