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Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce
Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this d...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226471/ https://www.ncbi.nlm.nih.gov/pubmed/37097029 http://dx.doi.org/10.1097/PCC.0000000000003263 |
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author | Carrol, Enitan D. Ranjit, Suchitra Menon, Kusum Bennett, Tellen D. Sanchez-Pinto, L. Nelson Zimmerman, Jerry J. Souza, Daniela C. Sorce, Lauren R. Randolph, Adrienne G. Ishimine, Paul Flauzino de Oliveira, Claudio Lodha, Rakesh Harmon, Lori Watson, R. Scott Schlapbach, Luregn J. Kissoon, Niranjan Argent, Andrew C. |
author_facet | Carrol, Enitan D. Ranjit, Suchitra Menon, Kusum Bennett, Tellen D. Sanchez-Pinto, L. Nelson Zimmerman, Jerry J. Souza, Daniela C. Sorce, Lauren R. Randolph, Adrienne G. Ishimine, Paul Flauzino de Oliveira, Claudio Lodha, Rakesh Harmon, Lori Watson, R. Scott Schlapbach, Luregn J. Kissoon, Niranjan Argent, Andrew C. |
author_sort | Carrol, Enitan D. |
collection | PubMed |
description | Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this definition has been widely acknowledged; however, important considerations about less-resourced and more diverse settings pose challenges to its use globally. To improve applicability and relevance globally, the Pediatric Sepsis Definition Taskforce sought to develop a conceptual framework and rationale of the critical aspects and context-specific factors that must be considered for the optimal operationalization of future pediatric sepsis definitions. It is important to address challenges in developing a set of pediatric sepsis criteria which capture manifestations of illnesses with vastly different etiologies and underlying mechanisms. Ideal criteria need to be unambiguous, and capable of adapting to the different contexts in which children with suspected infections are present around the globe. Additionally, criteria need to facilitate early recognition and timely escalation of treatment to prevent progression and limit life-threatening organ dysfunction. To address these challenges, locally adaptable solutions are required, which permit individualized care based on available resources and the pretest probability of sepsis. This should facilitate affordable diagnostics which support risk stratification and prediction of likely treatment responses, and solutions for locally relevant outcome measures. For this purpose, global collaborative databases need to be established, using minimum variable datasets from routinely collected data. In summary, a “Think globally, act locally” approach is required. |
format | Online Article Text |
id | pubmed-10226471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-102264712023-05-30 Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce Carrol, Enitan D. Ranjit, Suchitra Menon, Kusum Bennett, Tellen D. Sanchez-Pinto, L. Nelson Zimmerman, Jerry J. Souza, Daniela C. Sorce, Lauren R. Randolph, Adrienne G. Ishimine, Paul Flauzino de Oliveira, Claudio Lodha, Rakesh Harmon, Lori Watson, R. Scott Schlapbach, Luregn J. Kissoon, Niranjan Argent, Andrew C. Pediatr Crit Care Med Online Special Article Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this definition has been widely acknowledged; however, important considerations about less-resourced and more diverse settings pose challenges to its use globally. To improve applicability and relevance globally, the Pediatric Sepsis Definition Taskforce sought to develop a conceptual framework and rationale of the critical aspects and context-specific factors that must be considered for the optimal operationalization of future pediatric sepsis definitions. It is important to address challenges in developing a set of pediatric sepsis criteria which capture manifestations of illnesses with vastly different etiologies and underlying mechanisms. Ideal criteria need to be unambiguous, and capable of adapting to the different contexts in which children with suspected infections are present around the globe. Additionally, criteria need to facilitate early recognition and timely escalation of treatment to prevent progression and limit life-threatening organ dysfunction. To address these challenges, locally adaptable solutions are required, which permit individualized care based on available resources and the pretest probability of sepsis. This should facilitate affordable diagnostics which support risk stratification and prediction of likely treatment responses, and solutions for locally relevant outcome measures. For this purpose, global collaborative databases need to be established, using minimum variable datasets from routinely collected data. In summary, a “Think globally, act locally” approach is required. Lippincott Williams & Wilkins 2023-04-25 2023-06 /pmc/articles/PMC10226471/ /pubmed/37097029 http://dx.doi.org/10.1097/PCC.0000000000003263 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Online Special Article Carrol, Enitan D. Ranjit, Suchitra Menon, Kusum Bennett, Tellen D. Sanchez-Pinto, L. Nelson Zimmerman, Jerry J. Souza, Daniela C. Sorce, Lauren R. Randolph, Adrienne G. Ishimine, Paul Flauzino de Oliveira, Claudio Lodha, Rakesh Harmon, Lori Watson, R. Scott Schlapbach, Luregn J. Kissoon, Niranjan Argent, Andrew C. Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce |
title | Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce |
title_full | Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce |
title_fullStr | Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce |
title_full_unstemmed | Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce |
title_short | Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce |
title_sort | operationalizing appropriate sepsis definitions in children worldwide: considerations for the pediatric sepsis definition taskforce |
topic | Online Special Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226471/ https://www.ncbi.nlm.nih.gov/pubmed/37097029 http://dx.doi.org/10.1097/PCC.0000000000003263 |
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