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Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce

Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this d...

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Autores principales: Carrol, Enitan D., Ranjit, Suchitra, Menon, Kusum, Bennett, Tellen D., Sanchez-Pinto, L. Nelson, Zimmerman, Jerry J., Souza, Daniela C., Sorce, Lauren R., Randolph, Adrienne G., Ishimine, Paul, Flauzino de Oliveira, Claudio, Lodha, Rakesh, Harmon, Lori, Watson, R. Scott, Schlapbach, Luregn J., Kissoon, Niranjan, Argent, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226471/
https://www.ncbi.nlm.nih.gov/pubmed/37097029
http://dx.doi.org/10.1097/PCC.0000000000003263
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author Carrol, Enitan D.
Ranjit, Suchitra
Menon, Kusum
Bennett, Tellen D.
Sanchez-Pinto, L. Nelson
Zimmerman, Jerry J.
Souza, Daniela C.
Sorce, Lauren R.
Randolph, Adrienne G.
Ishimine, Paul
Flauzino de Oliveira, Claudio
Lodha, Rakesh
Harmon, Lori
Watson, R. Scott
Schlapbach, Luregn J.
Kissoon, Niranjan
Argent, Andrew C.
author_facet Carrol, Enitan D.
Ranjit, Suchitra
Menon, Kusum
Bennett, Tellen D.
Sanchez-Pinto, L. Nelson
Zimmerman, Jerry J.
Souza, Daniela C.
Sorce, Lauren R.
Randolph, Adrienne G.
Ishimine, Paul
Flauzino de Oliveira, Claudio
Lodha, Rakesh
Harmon, Lori
Watson, R. Scott
Schlapbach, Luregn J.
Kissoon, Niranjan
Argent, Andrew C.
author_sort Carrol, Enitan D.
collection PubMed
description Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this definition has been widely acknowledged; however, important considerations about less-resourced and more diverse settings pose challenges to its use globally. To improve applicability and relevance globally, the Pediatric Sepsis Definition Taskforce sought to develop a conceptual framework and rationale of the critical aspects and context-specific factors that must be considered for the optimal operationalization of future pediatric sepsis definitions. It is important to address challenges in developing a set of pediatric sepsis criteria which capture manifestations of illnesses with vastly different etiologies and underlying mechanisms. Ideal criteria need to be unambiguous, and capable of adapting to the different contexts in which children with suspected infections are present around the globe. Additionally, criteria need to facilitate early recognition and timely escalation of treatment to prevent progression and limit life-threatening organ dysfunction. To address these challenges, locally adaptable solutions are required, which permit individualized care based on available resources and the pretest probability of sepsis. This should facilitate affordable diagnostics which support risk stratification and prediction of likely treatment responses, and solutions for locally relevant outcome measures. For this purpose, global collaborative databases need to be established, using minimum variable datasets from routinely collected data. In summary, a “Think globally, act locally” approach is required.
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spelling pubmed-102264712023-05-30 Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce Carrol, Enitan D. Ranjit, Suchitra Menon, Kusum Bennett, Tellen D. Sanchez-Pinto, L. Nelson Zimmerman, Jerry J. Souza, Daniela C. Sorce, Lauren R. Randolph, Adrienne G. Ishimine, Paul Flauzino de Oliveira, Claudio Lodha, Rakesh Harmon, Lori Watson, R. Scott Schlapbach, Luregn J. Kissoon, Niranjan Argent, Andrew C. Pediatr Crit Care Med Online Special Article Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this definition has been widely acknowledged; however, important considerations about less-resourced and more diverse settings pose challenges to its use globally. To improve applicability and relevance globally, the Pediatric Sepsis Definition Taskforce sought to develop a conceptual framework and rationale of the critical aspects and context-specific factors that must be considered for the optimal operationalization of future pediatric sepsis definitions. It is important to address challenges in developing a set of pediatric sepsis criteria which capture manifestations of illnesses with vastly different etiologies and underlying mechanisms. Ideal criteria need to be unambiguous, and capable of adapting to the different contexts in which children with suspected infections are present around the globe. Additionally, criteria need to facilitate early recognition and timely escalation of treatment to prevent progression and limit life-threatening organ dysfunction. To address these challenges, locally adaptable solutions are required, which permit individualized care based on available resources and the pretest probability of sepsis. This should facilitate affordable diagnostics which support risk stratification and prediction of likely treatment responses, and solutions for locally relevant outcome measures. For this purpose, global collaborative databases need to be established, using minimum variable datasets from routinely collected data. In summary, a “Think globally, act locally” approach is required. Lippincott Williams & Wilkins 2023-04-25 2023-06 /pmc/articles/PMC10226471/ /pubmed/37097029 http://dx.doi.org/10.1097/PCC.0000000000003263 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Online Special Article
Carrol, Enitan D.
Ranjit, Suchitra
Menon, Kusum
Bennett, Tellen D.
Sanchez-Pinto, L. Nelson
Zimmerman, Jerry J.
Souza, Daniela C.
Sorce, Lauren R.
Randolph, Adrienne G.
Ishimine, Paul
Flauzino de Oliveira, Claudio
Lodha, Rakesh
Harmon, Lori
Watson, R. Scott
Schlapbach, Luregn J.
Kissoon, Niranjan
Argent, Andrew C.
Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce
title Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce
title_full Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce
title_fullStr Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce
title_full_unstemmed Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce
title_short Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce
title_sort operationalizing appropriate sepsis definitions in children worldwide: considerations for the pediatric sepsis definition taskforce
topic Online Special Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226471/
https://www.ncbi.nlm.nih.gov/pubmed/37097029
http://dx.doi.org/10.1097/PCC.0000000000003263
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