Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review

This study reviews the molecular mechanism of exercise-induced autophagy/mitophagy and its possible mechanism in delaying motor symptoms progressivity in Parkinson’s disease (PD). Relevant articles obtained from PubMed and EBSCOhost were reviewed. After analyzing the articles, it was found that auto...

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Autores principales: Goenawan, Hanna, Kiasati, Shabrina, Sylviana, Nova, Megantara, Imam, Lesmana, Ronny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226548/
https://www.ncbi.nlm.nih.gov/pubmed/37255530
http://dx.doi.org/10.2147/NDT.S401416
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author Goenawan, Hanna
Kiasati, Shabrina
Sylviana, Nova
Megantara, Imam
Lesmana, Ronny
author_facet Goenawan, Hanna
Kiasati, Shabrina
Sylviana, Nova
Megantara, Imam
Lesmana, Ronny
author_sort Goenawan, Hanna
collection PubMed
description This study reviews the molecular mechanism of exercise-induced autophagy/mitophagy and its possible mechanism in delaying motor symptoms progressivity in Parkinson’s disease (PD). Relevant articles obtained from PubMed and EBSCOhost were reviewed. After analyzing the articles, it was found that autophagy can be induced by exercise and can possibly be activated through the AMPK-ULK1 pathway. Mitophagy can also be induced by exercise and can possibly be activated through PINK1/Parkin pathway and AMPK-dependent pathway. Moreover, exercise-induced autophagy can decrease the accumulation of toxic α-synuclein aggregates in PD and therefore can delay motor symptoms progressivity.
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spelling pubmed-102265482023-05-30 Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review Goenawan, Hanna Kiasati, Shabrina Sylviana, Nova Megantara, Imam Lesmana, Ronny Neuropsychiatr Dis Treat Review This study reviews the molecular mechanism of exercise-induced autophagy/mitophagy and its possible mechanism in delaying motor symptoms progressivity in Parkinson’s disease (PD). Relevant articles obtained from PubMed and EBSCOhost were reviewed. After analyzing the articles, it was found that autophagy can be induced by exercise and can possibly be activated through the AMPK-ULK1 pathway. Mitophagy can also be induced by exercise and can possibly be activated through PINK1/Parkin pathway and AMPK-dependent pathway. Moreover, exercise-induced autophagy can decrease the accumulation of toxic α-synuclein aggregates in PD and therefore can delay motor symptoms progressivity. Dove 2023-05-25 /pmc/articles/PMC10226548/ /pubmed/37255530 http://dx.doi.org/10.2147/NDT.S401416 Text en © 2023 Goenawan et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Goenawan, Hanna
Kiasati, Shabrina
Sylviana, Nova
Megantara, Imam
Lesmana, Ronny
Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review
title Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review
title_full Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review
title_fullStr Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review
title_full_unstemmed Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review
title_short Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review
title_sort exercise-induced autophagy ameliorates motor symptoms progressivity in parkinson’s disease through alpha-synuclein degradation: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226548/
https://www.ncbi.nlm.nih.gov/pubmed/37255530
http://dx.doi.org/10.2147/NDT.S401416
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