Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus

The influence of the microbiota on viral transmission and replication is well appreciated. However, its impact on retroviral pathogenesis outside of transmission/replication control remains unknown. Using murine leukemia virus (MuLV), we found that some commensal bacteria promoted the development of...

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Autores principales: Spring, Jessica, Khan, Aly A., Lara, Sophie, O’Grady, Kelly, Wilks, Jessica, Gurbuxani, Sandeep, Erickson, Steven, Fischbach, Michael, Jacobson, Amy, Chervonsky, Alexander, Golovkina, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226680/
https://www.ncbi.nlm.nih.gov/pubmed/36103821
http://dx.doi.org/10.1016/j.celrep.2022.111341
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author Spring, Jessica
Khan, Aly A.
Lara, Sophie
O’Grady, Kelly
Wilks, Jessica
Gurbuxani, Sandeep
Erickson, Steven
Fischbach, Michael
Jacobson, Amy
Chervonsky, Alexander
Golovkina, Tatyana
author_facet Spring, Jessica
Khan, Aly A.
Lara, Sophie
O’Grady, Kelly
Wilks, Jessica
Gurbuxani, Sandeep
Erickson, Steven
Fischbach, Michael
Jacobson, Amy
Chervonsky, Alexander
Golovkina, Tatyana
author_sort Spring, Jessica
collection PubMed
description The influence of the microbiota on viral transmission and replication is well appreciated. However, its impact on retroviral pathogenesis outside of transmission/replication control remains unknown. Using murine leukemia virus (MuLV), we found that some commensal bacteria promoted the development of leukemia induced by this retrovirus. The promotion of leukemia development by commensals is due to suppression of the adaptive immune response through upregulation of several negative regulators of immunity. These negative regulators include Serpinb9b and Rnf128, which are associated with a poor prognosis of some spontaneous human cancers. Upregulation of Serpinb9b is mediated by sensing of bacteria by the NOD1/NOD2/RIPK2 pathway. This work describes a mechanism by which the microbiota enhances tumorigenesis within gut-distant organs and points at potential targets for cancer therapy.
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spelling pubmed-102266802023-05-29 Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus Spring, Jessica Khan, Aly A. Lara, Sophie O’Grady, Kelly Wilks, Jessica Gurbuxani, Sandeep Erickson, Steven Fischbach, Michael Jacobson, Amy Chervonsky, Alexander Golovkina, Tatyana Cell Rep Article The influence of the microbiota on viral transmission and replication is well appreciated. However, its impact on retroviral pathogenesis outside of transmission/replication control remains unknown. Using murine leukemia virus (MuLV), we found that some commensal bacteria promoted the development of leukemia induced by this retrovirus. The promotion of leukemia development by commensals is due to suppression of the adaptive immune response through upregulation of several negative regulators of immunity. These negative regulators include Serpinb9b and Rnf128, which are associated with a poor prognosis of some spontaneous human cancers. Upregulation of Serpinb9b is mediated by sensing of bacteria by the NOD1/NOD2/RIPK2 pathway. This work describes a mechanism by which the microbiota enhances tumorigenesis within gut-distant organs and points at potential targets for cancer therapy. 2022-09-13 /pmc/articles/PMC10226680/ /pubmed/36103821 http://dx.doi.org/10.1016/j.celrep.2022.111341 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Spring, Jessica
Khan, Aly A.
Lara, Sophie
O’Grady, Kelly
Wilks, Jessica
Gurbuxani, Sandeep
Erickson, Steven
Fischbach, Michael
Jacobson, Amy
Chervonsky, Alexander
Golovkina, Tatyana
Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
title Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
title_full Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
title_fullStr Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
title_full_unstemmed Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
title_short Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
title_sort gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226680/
https://www.ncbi.nlm.nih.gov/pubmed/36103821
http://dx.doi.org/10.1016/j.celrep.2022.111341
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