Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2

The emergence of SARS-CoV-2 has seriously affected the lives of people worldwide. Clarifying the attenuation rule of SARS-CoV-2 neutralizing antibody (NAb) in vivo is the key to prevent reinfection and recurrence of virus. Currently, the commonly used methods for detecting NAb include virus neutrali...

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Autores principales: Chen, Chunxia, Liang, Jiahui, Hu, Hangzhan, Li, Xiaoquan, Wang, Li, Wang, Zhizeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226777/
https://www.ncbi.nlm.nih.gov/pubmed/37257735
http://dx.doi.org/10.1016/j.ab.2023.115199
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author Chen, Chunxia
Liang, Jiahui
Hu, Hangzhan
Li, Xiaoquan
Wang, Li
Wang, Zhizeng
author_facet Chen, Chunxia
Liang, Jiahui
Hu, Hangzhan
Li, Xiaoquan
Wang, Li
Wang, Zhizeng
author_sort Chen, Chunxia
collection PubMed
description The emergence of SARS-CoV-2 has seriously affected the lives of people worldwide. Clarifying the attenuation rule of SARS-CoV-2 neutralizing antibody (NAb) in vivo is the key to prevent reinfection and recurrence of virus. Currently, the commonly used methods for detecting NAb include virus neutralization tests, pseudovirus neutralization assays, lateral flow immunochromatography and enzyme-linked immunosorbent assays. The detection of NAb not only can be used to evaluate the level of immunity after vaccination or infection but also can provide important theoretical support for virus reinfection, recurrence and vaccine iteration. In this research, the related technologies of SARS-CoV-2 NAb detection were reviewed, aiming to provide better research ideas for SARS-CoV-2 epidemic prevention and control.
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spelling pubmed-102267772023-05-30 Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2 Chen, Chunxia Liang, Jiahui Hu, Hangzhan Li, Xiaoquan Wang, Li Wang, Zhizeng Anal Biochem Article The emergence of SARS-CoV-2 has seriously affected the lives of people worldwide. Clarifying the attenuation rule of SARS-CoV-2 neutralizing antibody (NAb) in vivo is the key to prevent reinfection and recurrence of virus. Currently, the commonly used methods for detecting NAb include virus neutralization tests, pseudovirus neutralization assays, lateral flow immunochromatography and enzyme-linked immunosorbent assays. The detection of NAb not only can be used to evaluate the level of immunity after vaccination or infection but also can provide important theoretical support for virus reinfection, recurrence and vaccine iteration. In this research, the related technologies of SARS-CoV-2 NAb detection were reviewed, aiming to provide better research ideas for SARS-CoV-2 epidemic prevention and control. Elsevier Inc. 2023-07-15 2023-05-29 /pmc/articles/PMC10226777/ /pubmed/37257735 http://dx.doi.org/10.1016/j.ab.2023.115199 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chen, Chunxia
Liang, Jiahui
Hu, Hangzhan
Li, Xiaoquan
Wang, Li
Wang, Zhizeng
Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2
title Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2
title_full Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2
title_fullStr Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2
title_full_unstemmed Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2
title_short Research progress in methods for detecting neutralizing antibodies against SARS-CoV-2
title_sort research progress in methods for detecting neutralizing antibodies against sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226777/
https://www.ncbi.nlm.nih.gov/pubmed/37257735
http://dx.doi.org/10.1016/j.ab.2023.115199
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