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Transition Substitution of Desired Bases in Human Pluripotent Stem Cells with Base Editors: A Step-by-Step Guide

The recent advances in human pluripotent stem cells (hPSCs) enable to precisely edit the desired bases in hPSCs to be used for the establishment of isogenic disease models and autologous ex vivo cell therapy. The knock-in approach based on the homologous directed repair with Cas9 endonuclease, causi...

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Detalles Bibliográficos
Autores principales: Park, Ju-Chan, Kim, Keun-Tae, Jang, Hyeon-Ki, Cha, Hyuk-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226858/
https://www.ncbi.nlm.nih.gov/pubmed/36823978
http://dx.doi.org/10.15283/ijsc22171

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