Cargando…
Non-linear association between body weight and functional outcome after acute ischemic stroke
This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into underweight (< 18.5 kg/m(2)), normal weigh...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226986/ https://www.ncbi.nlm.nih.gov/pubmed/37248256 http://dx.doi.org/10.1038/s41598-023-35894-y |
_version_ | 1785050673220419584 |
---|---|
author | Wakisaka, Kayo Matsuo, Ryu Matsumoto, Koutarou Nohara, Yasunobu Irie, Fumi Wakisaka, Yoshinobu Ago, Tetsuro Nakashima, Naoki Kamouchi, Masahiro Kitazono, Takanari |
author_facet | Wakisaka, Kayo Matsuo, Ryu Matsumoto, Koutarou Nohara, Yasunobu Irie, Fumi Wakisaka, Yoshinobu Ago, Tetsuro Nakashima, Naoki Kamouchi, Masahiro Kitazono, Takanari |
author_sort | Wakisaka, Kayo |
collection | PubMed |
description | This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into underweight (< 18.5 kg/m(2)), normal weight (18.5–22.9 kg/m(2)), overweight (23.0–24.9 kg/m(2)), and obesity (≥ 25.0 kg/m(2)). The association between BMI and a poor functional outcome (modified Rankin Scale [mRS] score: 3–6) was evaluated. We included 11,749 patients with acute ischemic stroke (70.3 ± 12.2 years, 36.1% women). The risk of a 3-month poor functional outcome was higher for underweight, lower for overweight, and did not change for obesity in reference to a normal weight even after adjusting for covariates by logistic regression analysis. Restricted cubic splines and SHapley Additive exPlanation values in eXtreme Gradient Boosting model also showed non-linear relationships. Associations between BMI and a poor functional outcome were maintained even after excluding death (mRS score: 3–5) or including mild disability (mRS score: 2–6) as the outcome. The associations were strong in older patients, non-diabetic patients, and patients with mild stroke. Body weight has a non-linear relationship with the risk of a poor functional outcome after acute ischemic stroke. |
format | Online Article Text |
id | pubmed-10226986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102269862023-05-31 Non-linear association between body weight and functional outcome after acute ischemic stroke Wakisaka, Kayo Matsuo, Ryu Matsumoto, Koutarou Nohara, Yasunobu Irie, Fumi Wakisaka, Yoshinobu Ago, Tetsuro Nakashima, Naoki Kamouchi, Masahiro Kitazono, Takanari Sci Rep Article This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into underweight (< 18.5 kg/m(2)), normal weight (18.5–22.9 kg/m(2)), overweight (23.0–24.9 kg/m(2)), and obesity (≥ 25.0 kg/m(2)). The association between BMI and a poor functional outcome (modified Rankin Scale [mRS] score: 3–6) was evaluated. We included 11,749 patients with acute ischemic stroke (70.3 ± 12.2 years, 36.1% women). The risk of a 3-month poor functional outcome was higher for underweight, lower for overweight, and did not change for obesity in reference to a normal weight even after adjusting for covariates by logistic regression analysis. Restricted cubic splines and SHapley Additive exPlanation values in eXtreme Gradient Boosting model also showed non-linear relationships. Associations between BMI and a poor functional outcome were maintained even after excluding death (mRS score: 3–5) or including mild disability (mRS score: 2–6) as the outcome. The associations were strong in older patients, non-diabetic patients, and patients with mild stroke. Body weight has a non-linear relationship with the risk of a poor functional outcome after acute ischemic stroke. Nature Publishing Group UK 2023-05-29 /pmc/articles/PMC10226986/ /pubmed/37248256 http://dx.doi.org/10.1038/s41598-023-35894-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wakisaka, Kayo Matsuo, Ryu Matsumoto, Koutarou Nohara, Yasunobu Irie, Fumi Wakisaka, Yoshinobu Ago, Tetsuro Nakashima, Naoki Kamouchi, Masahiro Kitazono, Takanari Non-linear association between body weight and functional outcome after acute ischemic stroke |
title | Non-linear association between body weight and functional outcome after acute ischemic stroke |
title_full | Non-linear association between body weight and functional outcome after acute ischemic stroke |
title_fullStr | Non-linear association between body weight and functional outcome after acute ischemic stroke |
title_full_unstemmed | Non-linear association between body weight and functional outcome after acute ischemic stroke |
title_short | Non-linear association between body weight and functional outcome after acute ischemic stroke |
title_sort | non-linear association between body weight and functional outcome after acute ischemic stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226986/ https://www.ncbi.nlm.nih.gov/pubmed/37248256 http://dx.doi.org/10.1038/s41598-023-35894-y |
work_keys_str_mv | AT wakisakakayo nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT matsuoryu nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT matsumotokoutarou nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT noharayasunobu nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT iriefumi nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT wakisakayoshinobu nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT agotetsuro nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT nakashimanaoki nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT kamouchimasahiro nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke AT kitazonotakanari nonlinearassociationbetweenbodyweightandfunctionaloutcomeafteracuteischemicstroke |