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Non-linear association between body weight and functional outcome after acute ischemic stroke

This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into underweight (< 18.5 kg/m(2)), normal weigh...

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Autores principales: Wakisaka, Kayo, Matsuo, Ryu, Matsumoto, Koutarou, Nohara, Yasunobu, Irie, Fumi, Wakisaka, Yoshinobu, Ago, Tetsuro, Nakashima, Naoki, Kamouchi, Masahiro, Kitazono, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226986/
https://www.ncbi.nlm.nih.gov/pubmed/37248256
http://dx.doi.org/10.1038/s41598-023-35894-y
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author Wakisaka, Kayo
Matsuo, Ryu
Matsumoto, Koutarou
Nohara, Yasunobu
Irie, Fumi
Wakisaka, Yoshinobu
Ago, Tetsuro
Nakashima, Naoki
Kamouchi, Masahiro
Kitazono, Takanari
author_facet Wakisaka, Kayo
Matsuo, Ryu
Matsumoto, Koutarou
Nohara, Yasunobu
Irie, Fumi
Wakisaka, Yoshinobu
Ago, Tetsuro
Nakashima, Naoki
Kamouchi, Masahiro
Kitazono, Takanari
author_sort Wakisaka, Kayo
collection PubMed
description This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into underweight (< 18.5 kg/m(2)), normal weight (18.5–22.9 kg/m(2)), overweight (23.0–24.9 kg/m(2)), and obesity (≥ 25.0 kg/m(2)). The association between BMI and a poor functional outcome (modified Rankin Scale [mRS] score: 3–6) was evaluated. We included 11,749 patients with acute ischemic stroke (70.3 ± 12.2 years, 36.1% women). The risk of a 3-month poor functional outcome was higher for underweight, lower for overweight, and did not change for obesity in reference to a normal weight even after adjusting for covariates by logistic regression analysis. Restricted cubic splines and SHapley Additive exPlanation values in eXtreme Gradient Boosting model also showed non-linear relationships. Associations between BMI and a poor functional outcome were maintained even after excluding death (mRS score: 3–5) or including mild disability (mRS score: 2–6) as the outcome. The associations were strong in older patients, non-diabetic patients, and patients with mild stroke. Body weight has a non-linear relationship with the risk of a poor functional outcome after acute ischemic stroke.
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spelling pubmed-102269862023-05-31 Non-linear association between body weight and functional outcome after acute ischemic stroke Wakisaka, Kayo Matsuo, Ryu Matsumoto, Koutarou Nohara, Yasunobu Irie, Fumi Wakisaka, Yoshinobu Ago, Tetsuro Nakashima, Naoki Kamouchi, Masahiro Kitazono, Takanari Sci Rep Article This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into underweight (< 18.5 kg/m(2)), normal weight (18.5–22.9 kg/m(2)), overweight (23.0–24.9 kg/m(2)), and obesity (≥ 25.0 kg/m(2)). The association between BMI and a poor functional outcome (modified Rankin Scale [mRS] score: 3–6) was evaluated. We included 11,749 patients with acute ischemic stroke (70.3 ± 12.2 years, 36.1% women). The risk of a 3-month poor functional outcome was higher for underweight, lower for overweight, and did not change for obesity in reference to a normal weight even after adjusting for covariates by logistic regression analysis. Restricted cubic splines and SHapley Additive exPlanation values in eXtreme Gradient Boosting model also showed non-linear relationships. Associations between BMI and a poor functional outcome were maintained even after excluding death (mRS score: 3–5) or including mild disability (mRS score: 2–6) as the outcome. The associations were strong in older patients, non-diabetic patients, and patients with mild stroke. Body weight has a non-linear relationship with the risk of a poor functional outcome after acute ischemic stroke. Nature Publishing Group UK 2023-05-29 /pmc/articles/PMC10226986/ /pubmed/37248256 http://dx.doi.org/10.1038/s41598-023-35894-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wakisaka, Kayo
Matsuo, Ryu
Matsumoto, Koutarou
Nohara, Yasunobu
Irie, Fumi
Wakisaka, Yoshinobu
Ago, Tetsuro
Nakashima, Naoki
Kamouchi, Masahiro
Kitazono, Takanari
Non-linear association between body weight and functional outcome after acute ischemic stroke
title Non-linear association between body weight and functional outcome after acute ischemic stroke
title_full Non-linear association between body weight and functional outcome after acute ischemic stroke
title_fullStr Non-linear association between body weight and functional outcome after acute ischemic stroke
title_full_unstemmed Non-linear association between body weight and functional outcome after acute ischemic stroke
title_short Non-linear association between body weight and functional outcome after acute ischemic stroke
title_sort non-linear association between body weight and functional outcome after acute ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226986/
https://www.ncbi.nlm.nih.gov/pubmed/37248256
http://dx.doi.org/10.1038/s41598-023-35894-y
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