From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia

Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools. Deoxycytidine kinase is the rate-limiting enzyme of the salvage pathway and it has recently emerged as a target for anti-proliferative therapie...

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Detalles Bibliográficos
Autores principales: Saez-Ayala, Magali, Hoffer, Laurent, Abel, Sébastien, Ben Yaala, Khaoula, Sicard, Benoit, Andrieu, Guillaume P., Latiri, Mehdi, Davison, Emma K., Ciufolini, Marco A., Brémond, Paul, Rebuffet, Etienne, Roche, Philippe, Derviaux, Carine, Voisset, Edwige, Montersino, Camille, Castellano, Remy, Collette, Yves, Asnafi, Vahid, Betzi, Stéphane, Dubreuil, Patrice, Combes, Sébastien, Morelli, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227015/
https://www.ncbi.nlm.nih.gov/pubmed/37248212
http://dx.doi.org/10.1038/s41467-023-38668-2

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