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A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling
Beam tracking X-ray Phase Contrast Imaging is a “Shack-Hartmann” type approach which uses a pre-sample mask to split the x-rays into “beamlets” which are interrogated by a detector with sufficient resolution. The ultimate spatial resolution is determined by the size of the mask apertures, however ac...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227046/ https://www.ncbi.nlm.nih.gov/pubmed/37248325 http://dx.doi.org/10.1038/s41598-023-35901-2 |
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author | Lioliou, G. Navarrete-León, C. Astolfo, A. Savvidis, S. Bate, D. Endrizzi, M. Hagen, C. K. Olivo, A. |
author_facet | Lioliou, G. Navarrete-León, C. Astolfo, A. Savvidis, S. Bate, D. Endrizzi, M. Hagen, C. K. Olivo, A. |
author_sort | Lioliou, G. |
collection | PubMed |
description | Beam tracking X-ray Phase Contrast Imaging is a “Shack-Hartmann” type approach which uses a pre-sample mask to split the x-rays into “beamlets” which are interrogated by a detector with sufficient resolution. The ultimate spatial resolution is determined by the size of the mask apertures, however achieving this resolution level requires “stepping” the sample or the mask in increments equal to the aperture size (“dithering”). If an array of circular apertures is used (which also provides two-dimensional phase sensitivity) instead of long parallel slits, this stepping needs to be carried out in two directions, which lengthens scan times significantly. We present a mask design obtained by offsetting rows of circular apertures, allowing for two-dimensional sensitivity and isotropic resolution while requiring sample or mask stepping in one direction only. We present images of custom-built phantoms and biological specimens, demonstrating that quantitative phase retrieval and near aperture-limited spatial resolutions are obtained in two orthogonal directions. |
format | Online Article Text |
id | pubmed-10227046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102270462023-05-31 A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling Lioliou, G. Navarrete-León, C. Astolfo, A. Savvidis, S. Bate, D. Endrizzi, M. Hagen, C. K. Olivo, A. Sci Rep Article Beam tracking X-ray Phase Contrast Imaging is a “Shack-Hartmann” type approach which uses a pre-sample mask to split the x-rays into “beamlets” which are interrogated by a detector with sufficient resolution. The ultimate spatial resolution is determined by the size of the mask apertures, however achieving this resolution level requires “stepping” the sample or the mask in increments equal to the aperture size (“dithering”). If an array of circular apertures is used (which also provides two-dimensional phase sensitivity) instead of long parallel slits, this stepping needs to be carried out in two directions, which lengthens scan times significantly. We present a mask design obtained by offsetting rows of circular apertures, allowing for two-dimensional sensitivity and isotropic resolution while requiring sample or mask stepping in one direction only. We present images of custom-built phantoms and biological specimens, demonstrating that quantitative phase retrieval and near aperture-limited spatial resolutions are obtained in two orthogonal directions. Nature Publishing Group UK 2023-05-29 /pmc/articles/PMC10227046/ /pubmed/37248325 http://dx.doi.org/10.1038/s41598-023-35901-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lioliou, G. Navarrete-León, C. Astolfo, A. Savvidis, S. Bate, D. Endrizzi, M. Hagen, C. K. Olivo, A. A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling |
title | A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling |
title_full | A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling |
title_fullStr | A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling |
title_full_unstemmed | A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling |
title_short | A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling |
title_sort | laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227046/ https://www.ncbi.nlm.nih.gov/pubmed/37248325 http://dx.doi.org/10.1038/s41598-023-35901-2 |
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