Structural insights into the bi-specific cross-over dual variable antibody architecture by cryo-EM

Multi-specific antibodies (msAbs) are being developed as next generation antibody-based therapeutics. Knowledge of the three-dimensional structures, in the full antibody context, of their fragment antigen-binding (Fab) moieties with or without bound antigens is key to elucidating their therapeutic e...

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Detalles Bibliográficos
Autores principales: Fernandez-Martinez, David, Tully, Mark D., Leonard, Gordon, Mathieu, Magali, Kandiah, Eaazhisai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227088/
https://www.ncbi.nlm.nih.gov/pubmed/37248285
http://dx.doi.org/10.1038/s41598-023-35678-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227088/
https://www.ncbi.nlm.nih.gov/pubmed/37248285
http://dx.doi.org/10.1038/s41598-023-35678-4

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