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Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants
PURPOSE: The aim of this study was to evaluate the possible relationship between four single nucleotide polymorphisms of hemangioma-linked genes encoding for anthrax toxin receptor 1 (ANTXR1 G976A), R kinase insert domain receptor (KDR T1444C), adrenoceptor beta 2 (ADRB C79CG), and insulin-like grow...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227102/ https://www.ncbi.nlm.nih.gov/pubmed/36656337 http://dx.doi.org/10.1007/s00381-023-05824-4 |
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author | Kosik, Katarzyna Szpecht, Dawid Karbowski, Łukasz Al-Saad, Salwan R. Chmielarz-Czarnocińska, Anna Minta, Marcin Sowińska, Anna Strauss, Ewa |
author_facet | Kosik, Katarzyna Szpecht, Dawid Karbowski, Łukasz Al-Saad, Salwan R. Chmielarz-Czarnocińska, Anna Minta, Marcin Sowińska, Anna Strauss, Ewa |
author_sort | Kosik, Katarzyna |
collection | PubMed |
description | PURPOSE: The aim of this study was to evaluate the possible relationship between four single nucleotide polymorphisms of hemangioma-linked genes encoding for anthrax toxin receptor 1 (ANTXR1 G976A), R kinase insert domain receptor (KDR T1444C), adrenoceptor beta 2 (ADRB C79CG), and insulin-like growth factor 1 receptor (IGF-1R G3174A) and the occurrence of IVH in a population of preterm infants. METHODS: The study includes a population of 105 infants born from 24 + 0 to 32 + 0 weeks of gestation and hospitalized at the Department of Neonatology (III level hospital) of Poznan University of Medical Science. Intraventricular hemorrhage was diagnosed with the use of cranial ultrasound. The classification of intraventricular bleeding was based on the Papile IVH classification. RESULTS: The incidence of IVH was higher in infants with lower birth weight, lower APGAR scores, and low birth weight. The study revealed that IVH was approximately two times less likely to occur in infants with the allele G of IGF-1R 3174G > A. CONCLUSION: Identifying susceptible premature infants through genetic analysis could be a potential way to alleviate severe IVH and its subsequent consequences. Further research examining a wider range of relevant gene polymorphisms could help highlight any genetic patterns in this deleterious bleeding complication. |
format | Online Article Text |
id | pubmed-10227102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-102271022023-05-31 Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants Kosik, Katarzyna Szpecht, Dawid Karbowski, Łukasz Al-Saad, Salwan R. Chmielarz-Czarnocińska, Anna Minta, Marcin Sowińska, Anna Strauss, Ewa Childs Nerv Syst Original Article PURPOSE: The aim of this study was to evaluate the possible relationship between four single nucleotide polymorphisms of hemangioma-linked genes encoding for anthrax toxin receptor 1 (ANTXR1 G976A), R kinase insert domain receptor (KDR T1444C), adrenoceptor beta 2 (ADRB C79CG), and insulin-like growth factor 1 receptor (IGF-1R G3174A) and the occurrence of IVH in a population of preterm infants. METHODS: The study includes a population of 105 infants born from 24 + 0 to 32 + 0 weeks of gestation and hospitalized at the Department of Neonatology (III level hospital) of Poznan University of Medical Science. Intraventricular hemorrhage was diagnosed with the use of cranial ultrasound. The classification of intraventricular bleeding was based on the Papile IVH classification. RESULTS: The incidence of IVH was higher in infants with lower birth weight, lower APGAR scores, and low birth weight. The study revealed that IVH was approximately two times less likely to occur in infants with the allele G of IGF-1R 3174G > A. CONCLUSION: Identifying susceptible premature infants through genetic analysis could be a potential way to alleviate severe IVH and its subsequent consequences. Further research examining a wider range of relevant gene polymorphisms could help highlight any genetic patterns in this deleterious bleeding complication. Springer Berlin Heidelberg 2023-01-19 2023 /pmc/articles/PMC10227102/ /pubmed/36656337 http://dx.doi.org/10.1007/s00381-023-05824-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Kosik, Katarzyna Szpecht, Dawid Karbowski, Łukasz Al-Saad, Salwan R. Chmielarz-Czarnocińska, Anna Minta, Marcin Sowińska, Anna Strauss, Ewa Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants |
title | Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants |
title_full | Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants |
title_fullStr | Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants |
title_full_unstemmed | Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants |
title_short | Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants |
title_sort | hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227102/ https://www.ncbi.nlm.nih.gov/pubmed/36656337 http://dx.doi.org/10.1007/s00381-023-05824-4 |
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