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Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure
OBJECTIVE: Central sleep apnea (CSA) is associated with increased morbidity and mortality in patients with heart failure (HF). We aimed to explore the effectiveness of phrenic nerve stimulation (PNS) on CSA in patients with HF. METHODS: This was a prospective and non-randomized study. The stimulatio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227108/ https://www.ncbi.nlm.nih.gov/pubmed/35978055 http://dx.doi.org/10.1007/s11325-022-02699-8 |
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author | Wang, Youmeng Schoebel, Juliane Han, Jinming Kraemer, Jan F. Toncar, Theresa Siegert, Jacob Penzel, Thomas Schöbel, Christoph |
author_facet | Wang, Youmeng Schoebel, Juliane Han, Jinming Kraemer, Jan F. Toncar, Theresa Siegert, Jacob Penzel, Thomas Schöbel, Christoph |
author_sort | Wang, Youmeng |
collection | PubMed |
description | OBJECTIVE: Central sleep apnea (CSA) is associated with increased morbidity and mortality in patients with heart failure (HF). We aimed to explore the effectiveness of phrenic nerve stimulation (PNS) on CSA in patients with HF. METHODS: This was a prospective and non-randomized study. The stimulation lead was inserted into the right brachiocephalic vein and attached to a proprietary neurostimulator. Monitoring was conducted during the implantation process, and all individuals underwent two-night polysomnography. RESULTS: A total of nine subjects with HF and CSA were enrolled in our center. There was a significant decrease in the apnea–hypopnea index (41 ± 18 vs 29 ± 25, p = 0.02) and an increase in mean arterial oxygen saturation (SaO2) (93% ± 1% vs 95% ± 2%, p = 0.03) after PNS treatment. We did not observe any significant differences of oxygen desaturation index (ODI) and SaO2 < 90% (T90) following PNS. Unilateral phrenic nerve stimulation might also categorically improve the severity of sleep apnea. CONCLUSION: In our non-randomized study, PNS may serve as a therapeutic approach for CSA in patients with HF. |
format | Online Article Text |
id | pubmed-10227108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-102271082023-05-31 Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure Wang, Youmeng Schoebel, Juliane Han, Jinming Kraemer, Jan F. Toncar, Theresa Siegert, Jacob Penzel, Thomas Schöbel, Christoph Sleep Breath Sleep Breathing Physiology and Disorders • Original Article OBJECTIVE: Central sleep apnea (CSA) is associated with increased morbidity and mortality in patients with heart failure (HF). We aimed to explore the effectiveness of phrenic nerve stimulation (PNS) on CSA in patients with HF. METHODS: This was a prospective and non-randomized study. The stimulation lead was inserted into the right brachiocephalic vein and attached to a proprietary neurostimulator. Monitoring was conducted during the implantation process, and all individuals underwent two-night polysomnography. RESULTS: A total of nine subjects with HF and CSA were enrolled in our center. There was a significant decrease in the apnea–hypopnea index (41 ± 18 vs 29 ± 25, p = 0.02) and an increase in mean arterial oxygen saturation (SaO2) (93% ± 1% vs 95% ± 2%, p = 0.03) after PNS treatment. We did not observe any significant differences of oxygen desaturation index (ODI) and SaO2 < 90% (T90) following PNS. Unilateral phrenic nerve stimulation might also categorically improve the severity of sleep apnea. CONCLUSION: In our non-randomized study, PNS may serve as a therapeutic approach for CSA in patients with HF. Springer International Publishing 2022-08-17 2023 /pmc/articles/PMC10227108/ /pubmed/35978055 http://dx.doi.org/10.1007/s11325-022-02699-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Sleep Breathing Physiology and Disorders • Original Article Wang, Youmeng Schoebel, Juliane Han, Jinming Kraemer, Jan F. Toncar, Theresa Siegert, Jacob Penzel, Thomas Schöbel, Christoph Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure |
title | Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure |
title_full | Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure |
title_fullStr | Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure |
title_full_unstemmed | Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure |
title_short | Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure |
title_sort | phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure |
topic | Sleep Breathing Physiology and Disorders • Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227108/ https://www.ncbi.nlm.nih.gov/pubmed/35978055 http://dx.doi.org/10.1007/s11325-022-02699-8 |
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