Cargando…
Association of Chronic Kidney Disease With Atrial Fibrillation in the General Adult Population: A Nationwide Population‐Based Study
BACKGROUND: The incidences of atrial fibrillation (AF) and chronic kidney disease (CKD) are increasing, and AF is prevalent in patients with CKD. However, few studies have investigated the incidence or association of AF in a large CKD population from a longitudinal study. METHODS AND RESULTS: From a...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227274/ https://www.ncbi.nlm.nih.gov/pubmed/37066806 http://dx.doi.org/10.1161/JAHA.122.028496 |
_version_ | 1785050734347157504 |
---|---|
author | Kim, Seon‐Mi Jeong, Yujin Kim, Yae Lim Kang, Minjung Kang, Eunjeong Ryu, Hyunjin Kim, Yunmi Han, Seung Seok Ahn, Curie Oh, Kook‐Hwan |
author_facet | Kim, Seon‐Mi Jeong, Yujin Kim, Yae Lim Kang, Minjung Kang, Eunjeong Ryu, Hyunjin Kim, Yunmi Han, Seung Seok Ahn, Curie Oh, Kook‐Hwan |
author_sort | Kim, Seon‐Mi |
collection | PubMed |
description | BACKGROUND: The incidences of atrial fibrillation (AF) and chronic kidney disease (CKD) are increasing, and AF is prevalent in patients with CKD. However, few studies have investigated the incidence or association of AF in a large CKD population from a longitudinal study. METHODS AND RESULTS: From a nationwide cohort, a total of 4 827 987 Korean individuals without prior AF, who received biennial health checkups provided by the National Health Insurance Service between 2009 and 2012 in Korea, were analyzed. Incidence of AF was ascertained through the end of 2018. During a median follow‐up of 8.1 years, the annual incidence rate of AF was 1.17 per 1000 person‐years among subjects without CKD, 1.55 for stage 1 CKD, 1.86 for stage 2 CKD, 2.1 for stage 3 CKD, and 4.33 for stage 4 CKD. In Fine‐Gray regression models, CKD was associated with an increased risk of AF; the adjusted hazard ratios and 95% CIs of AF occurrence were 1.77 (1.69–1.85), 1.85 (1.80–1.91), 1.99 (1.95–2.04), and 4.04 (3.07–5.33) in individuals with CKD stages 1, 2, 3, and 4, respectively, compared with non‐CKD. The association between CKD and incident AF remained statistically significant after adjustment for multiple confounding factors and was consistent across subgroups stratified by sex and age. CONCLUSIONS: CKD is associated with an increased incidence of AF. Even mild CKD is associated with incident AF, and there was a stepwise increase in the risk of incident AF with a decrease in renal function. |
format | Online Article Text |
id | pubmed-10227274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102272742023-05-31 Association of Chronic Kidney Disease With Atrial Fibrillation in the General Adult Population: A Nationwide Population‐Based Study Kim, Seon‐Mi Jeong, Yujin Kim, Yae Lim Kang, Minjung Kang, Eunjeong Ryu, Hyunjin Kim, Yunmi Han, Seung Seok Ahn, Curie Oh, Kook‐Hwan J Am Heart Assoc Original Research BACKGROUND: The incidences of atrial fibrillation (AF) and chronic kidney disease (CKD) are increasing, and AF is prevalent in patients with CKD. However, few studies have investigated the incidence or association of AF in a large CKD population from a longitudinal study. METHODS AND RESULTS: From a nationwide cohort, a total of 4 827 987 Korean individuals without prior AF, who received biennial health checkups provided by the National Health Insurance Service between 2009 and 2012 in Korea, were analyzed. Incidence of AF was ascertained through the end of 2018. During a median follow‐up of 8.1 years, the annual incidence rate of AF was 1.17 per 1000 person‐years among subjects without CKD, 1.55 for stage 1 CKD, 1.86 for stage 2 CKD, 2.1 for stage 3 CKD, and 4.33 for stage 4 CKD. In Fine‐Gray regression models, CKD was associated with an increased risk of AF; the adjusted hazard ratios and 95% CIs of AF occurrence were 1.77 (1.69–1.85), 1.85 (1.80–1.91), 1.99 (1.95–2.04), and 4.04 (3.07–5.33) in individuals with CKD stages 1, 2, 3, and 4, respectively, compared with non‐CKD. The association between CKD and incident AF remained statistically significant after adjustment for multiple confounding factors and was consistent across subgroups stratified by sex and age. CONCLUSIONS: CKD is associated with an increased incidence of AF. Even mild CKD is associated with incident AF, and there was a stepwise increase in the risk of incident AF with a decrease in renal function. John Wiley and Sons Inc. 2023-04-17 /pmc/articles/PMC10227274/ /pubmed/37066806 http://dx.doi.org/10.1161/JAHA.122.028496 Text en © 2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Kim, Seon‐Mi Jeong, Yujin Kim, Yae Lim Kang, Minjung Kang, Eunjeong Ryu, Hyunjin Kim, Yunmi Han, Seung Seok Ahn, Curie Oh, Kook‐Hwan Association of Chronic Kidney Disease With Atrial Fibrillation in the General Adult Population: A Nationwide Population‐Based Study |
title | Association of Chronic Kidney Disease With Atrial Fibrillation in the General Adult Population: A Nationwide Population‐Based Study |
title_full | Association of Chronic Kidney Disease With Atrial Fibrillation in the General Adult Population: A Nationwide Population‐Based Study |
title_fullStr | Association of Chronic Kidney Disease With Atrial Fibrillation in the General Adult Population: A Nationwide Population‐Based Study |
title_full_unstemmed | Association of Chronic Kidney Disease With Atrial Fibrillation in the General Adult Population: A Nationwide Population‐Based Study |
title_short | Association of Chronic Kidney Disease With Atrial Fibrillation in the General Adult Population: A Nationwide Population‐Based Study |
title_sort | association of chronic kidney disease with atrial fibrillation in the general adult population: a nationwide population‐based study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227274/ https://www.ncbi.nlm.nih.gov/pubmed/37066806 http://dx.doi.org/10.1161/JAHA.122.028496 |
work_keys_str_mv | AT kimseonmi associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT jeongyujin associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT kimyaelim associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT kangminjung associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT kangeunjeong associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT ryuhyunjin associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT kimyunmi associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT hanseungseok associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT ahncurie associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy AT ohkookhwan associationofchronickidneydiseasewithatrialfibrillationinthegeneraladultpopulationanationwidepopulationbasedstudy |