Inflammation conditional genome editing mediated by the CRISPR-Cas9 system

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The specificity of CRISPR-Cas9 in response to particular pathological stimuli remains largely unexplored. Hence, we designed an inflammation-inducible CRISPR-Cas9 system by grafting a sequence that binds with NF-κB to the CRISPR-Cas9 framework, termed NBS-CRISPR. The genetic scissor function of this...

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Detalles Bibliográficos
Autores principales: Yuan, Tingting, Tang, Honglin, Xu, Xiaojie, Shao, Jingjing, Wu, Gaojun, Cho, Young-Chang, Ping, Yuan, Liang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227425/
https://www.ncbi.nlm.nih.gov/pubmed/37260750
http://dx.doi.org/10.1016/j.isci.2023.106872

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