Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

Epigenetic alterations are especially important in necrotizing enterocolitis (NEC). Here, we reported that histone deacetylase 8 (HDAC8) plays a previously unknown role in modulating arginine metabolism via acetylation of histone 3 lysine 9 (acetyl-H3K9) regulation during the pathogenesis of NEC. We...

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Detalles Bibliográficos
Autores principales: Guo, Ting, Hu, Shaohua, Xu, Weijue, Zhou, Jin, Chen, Feng, Gao, Tingting, Qu, Wenqian, Chen, Faling, Lv, Zhibao, Lu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227426/
https://www.ncbi.nlm.nih.gov/pubmed/37260741
http://dx.doi.org/10.1016/j.isci.2023.106882

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