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Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis

To define the metabolic requirements of hematopoiesis, we examined blood lineages in mice conditionally deficient in genes required for long-chain fatty acid oxidation (Cpt2), glutaminolysis (Gls), or mitochondrial pyruvate import (Mpc2). Genetic ablation of Cpt2 or Gls minimally impacted most blood...

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Detalles Bibliográficos
Autores principales:	Pizzato, Hannah A., Wang, Yahui, Wolfgang, Michael J., Finck, Brian N., Patti, Gary J., Bhattacharya, Deepta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227646/ https://www.ncbi.nlm.nih.gov/pubmed/37249600 http://dx.doi.org/10.1084/jem.20221373

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