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Does COVID-19 vaccination protect against pulmonary embolism?
The prevalence of venous thromboembolism (VTE) in COVID-19 patients is highly variable, depending on methodological and clinical factors, among which vaccination (1). The hypothesis of a possible protective role of vaccination in preventing pulmonary embolism (PE) in hospitalized COVID-19 patients h...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227776/ https://www.ncbi.nlm.nih.gov/pubmed/37274017 http://dx.doi.org/10.1186/s44158-023-00097-4 |
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author | Tantillo, Simona Cilloni, Nicola Guarnera, Martina Talarico, Francesco Citino, Mario Silingardi, Mauro Catalano, Leonardo Imbriani, Michele |
author_facet | Tantillo, Simona Cilloni, Nicola Guarnera, Martina Talarico, Francesco Citino, Mario Silingardi, Mauro Catalano, Leonardo Imbriani, Michele |
author_sort | Tantillo, Simona |
collection | PubMed |
description | The prevalence of venous thromboembolism (VTE) in COVID-19 patients is highly variable, depending on methodological and clinical factors, among which vaccination (1). The hypothesis of a possible protective role of vaccination in preventing pulmonary embolism (PE) in hospitalized COVID-19 patients has not been explored. The aim of the study was to evaluate PE prevalence in vaccinated versus unvaccinated hospitalized COVID-19 patients. We conducted a retrospective case–control study from 2021/11/01 to 2022/01/15; we reviewed all the chest computed topographies (chest-CT) performed because of a clinical suspicion for PE at our Institution. Sixty-two patients were included in the study: 27/62 (43.5%) were vaccinated and 35/62 (56.4%) were not. Vaccinated patients were older and with more comorbidities than unvaccinated people. Overall, PE was diagnosed in 19/62 patients (30.1% prevalence). CT Severity Score (CT-SS) differs between the two groups; not vaccinated patients had a more severe CT imaging than the vaccinated (< 0.00005). PE prevalence in ICU was 43.2% (16/37 patients), while in the Internal Medicine ward, it was 12% (3/25 cases). PE was significantly higher among unvaccinated people: 16/35 (45.7%) vs 3/27 (11.1%), OR p = 0.04. We observed a strong association between vaccination and protection from PE in hospitalized COVID-19 patients: morbidity was significantly lower in vaccinated versus not vaccinated patients. The issue of the protective role of vaccination in COVID-19-associated VTE should be addressed in adequately designed and powered future prospective studies. |
format | Online Article Text |
id | pubmed-10227776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102277762023-06-01 Does COVID-19 vaccination protect against pulmonary embolism? Tantillo, Simona Cilloni, Nicola Guarnera, Martina Talarico, Francesco Citino, Mario Silingardi, Mauro Catalano, Leonardo Imbriani, Michele J Anesth Analg Crit Care Letter to the Editor The prevalence of venous thromboembolism (VTE) in COVID-19 patients is highly variable, depending on methodological and clinical factors, among which vaccination (1). The hypothesis of a possible protective role of vaccination in preventing pulmonary embolism (PE) in hospitalized COVID-19 patients has not been explored. The aim of the study was to evaluate PE prevalence in vaccinated versus unvaccinated hospitalized COVID-19 patients. We conducted a retrospective case–control study from 2021/11/01 to 2022/01/15; we reviewed all the chest computed topographies (chest-CT) performed because of a clinical suspicion for PE at our Institution. Sixty-two patients were included in the study: 27/62 (43.5%) were vaccinated and 35/62 (56.4%) were not. Vaccinated patients were older and with more comorbidities than unvaccinated people. Overall, PE was diagnosed in 19/62 patients (30.1% prevalence). CT Severity Score (CT-SS) differs between the two groups; not vaccinated patients had a more severe CT imaging than the vaccinated (< 0.00005). PE prevalence in ICU was 43.2% (16/37 patients), while in the Internal Medicine ward, it was 12% (3/25 cases). PE was significantly higher among unvaccinated people: 16/35 (45.7%) vs 3/27 (11.1%), OR p = 0.04. We observed a strong association between vaccination and protection from PE in hospitalized COVID-19 patients: morbidity was significantly lower in vaccinated versus not vaccinated patients. The issue of the protective role of vaccination in COVID-19-associated VTE should be addressed in adequately designed and powered future prospective studies. BioMed Central 2023-05-30 /pmc/articles/PMC10227776/ /pubmed/37274017 http://dx.doi.org/10.1186/s44158-023-00097-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Letter to the Editor Tantillo, Simona Cilloni, Nicola Guarnera, Martina Talarico, Francesco Citino, Mario Silingardi, Mauro Catalano, Leonardo Imbriani, Michele Does COVID-19 vaccination protect against pulmonary embolism? |
title | Does COVID-19 vaccination protect against pulmonary embolism? |
title_full | Does COVID-19 vaccination protect against pulmonary embolism? |
title_fullStr | Does COVID-19 vaccination protect against pulmonary embolism? |
title_full_unstemmed | Does COVID-19 vaccination protect against pulmonary embolism? |
title_short | Does COVID-19 vaccination protect against pulmonary embolism? |
title_sort | does covid-19 vaccination protect against pulmonary embolism? |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227776/ https://www.ncbi.nlm.nih.gov/pubmed/37274017 http://dx.doi.org/10.1186/s44158-023-00097-4 |
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