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Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report
To show the MRI findings in a rare case of acute necrotizing encephalopathy following SARS-CoV-2 infection in an adult patient. Acute necrotizing encephalopathy is a rare condition characterized by the presence of symmetrical multifocal lesions with predominantly thalamic involvement, as well as the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227787/ https://www.ncbi.nlm.nih.gov/pubmed/37275566 http://dx.doi.org/10.1007/s42399-023-01491-3 |
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author | Hernández-Dehesa, Itzel Ariadna Alvarez-Castro, José Alfonso Aguilar-Hidalgo, Keren Magaly Santellán-Hernández, José Omar Castro-Soto, Fernando |
author_facet | Hernández-Dehesa, Itzel Ariadna Alvarez-Castro, José Alfonso Aguilar-Hidalgo, Keren Magaly Santellán-Hernández, José Omar Castro-Soto, Fernando |
author_sort | Hernández-Dehesa, Itzel Ariadna |
collection | PubMed |
description | To show the MRI findings in a rare case of acute necrotizing encephalopathy following SARS-CoV-2 infection in an adult patient. Acute necrotizing encephalopathy is a rare condition characterized by the presence of symmetrical multifocal lesions with predominantly thalamic involvement, as well as the brainstem and cerebellum. We describe the case of a 26-year-old male with a medical history of medulloblastoma that was disease-free after treatment and who tested positive in a PCR for SARS-CoV-2 in cerebrospinal fluid. Upon evaluation at the emergency department one week later, the patient was found to be awake, oriented, and focused and could maintain attention for periods of time. Mixed dysarthria persisted, characterized by being flaccid and hypokinetic. On magnetic resonance imaging, there were multiple hemorrhagic lesions with surrounding edema in the right thalamus with an extension to the posterior arm of the internal capsule, a smaller one in the left thalamus, and another expanded to the ipsilateral peduncle. Acute necrotizing encephalopathy presents a great clinical and diagnostic challenge, close clinical and radiological follow-up is essential, and magnetic susceptibility sequences (T2 or SWI) should be included in the diagnosis protocol. |
format | Online Article Text |
id | pubmed-10227787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-102277872023-06-01 Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report Hernández-Dehesa, Itzel Ariadna Alvarez-Castro, José Alfonso Aguilar-Hidalgo, Keren Magaly Santellán-Hernández, José Omar Castro-Soto, Fernando SN Compr Clin Med Case Report To show the MRI findings in a rare case of acute necrotizing encephalopathy following SARS-CoV-2 infection in an adult patient. Acute necrotizing encephalopathy is a rare condition characterized by the presence of symmetrical multifocal lesions with predominantly thalamic involvement, as well as the brainstem and cerebellum. We describe the case of a 26-year-old male with a medical history of medulloblastoma that was disease-free after treatment and who tested positive in a PCR for SARS-CoV-2 in cerebrospinal fluid. Upon evaluation at the emergency department one week later, the patient was found to be awake, oriented, and focused and could maintain attention for periods of time. Mixed dysarthria persisted, characterized by being flaccid and hypokinetic. On magnetic resonance imaging, there were multiple hemorrhagic lesions with surrounding edema in the right thalamus with an extension to the posterior arm of the internal capsule, a smaller one in the left thalamus, and another expanded to the ipsilateral peduncle. Acute necrotizing encephalopathy presents a great clinical and diagnostic challenge, close clinical and radiological follow-up is essential, and magnetic susceptibility sequences (T2 or SWI) should be included in the diagnosis protocol. Springer International Publishing 2023-05-30 2023 /pmc/articles/PMC10227787/ /pubmed/37275566 http://dx.doi.org/10.1007/s42399-023-01491-3 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Case Report Hernández-Dehesa, Itzel Ariadna Alvarez-Castro, José Alfonso Aguilar-Hidalgo, Keren Magaly Santellán-Hernández, José Omar Castro-Soto, Fernando Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report |
title | Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report |
title_full | Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report |
title_fullStr | Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report |
title_full_unstemmed | Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report |
title_short | Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report |
title_sort | acute necrotizing encephalopathy post sars-cov-2 infection in an adult patient: case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227787/ https://www.ncbi.nlm.nih.gov/pubmed/37275566 http://dx.doi.org/10.1007/s42399-023-01491-3 |
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