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Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study
BACKGROUND: To describe the occurrence, rate of geographic atrophy (GA) expansion, and changes in visual acuity (VA) after reabsorption of subfoveal pigment epithelial detachments (PED). METHODS: Included patients had reabsorption of a PED followed by GA. Patients underwent clinical examination with...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228064/ https://www.ncbi.nlm.nih.gov/pubmed/37254103 http://dx.doi.org/10.1186/s12886-023-02993-3 |
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author | Peng, Enoch T. Adrean, Sean D. |
author_facet | Peng, Enoch T. Adrean, Sean D. |
author_sort | Peng, Enoch T. |
collection | PubMed |
description | BACKGROUND: To describe the occurrence, rate of geographic atrophy (GA) expansion, and changes in visual acuity (VA) after reabsorption of subfoveal pigment epithelial detachments (PED). METHODS: Included patients had reabsorption of a PED followed by GA. Patients underwent clinical examination with SD-OCT. Images were classified by size with grading occurring post reabsorption. VA was recorded pre-reabsorption, post-reabsorption, and over time. RESULTS: The average age of the cohort, consisting of 22 eyes from 19 participants, was 86.9 years at reabsorption. Prior to reabsorption, the VA was 20/80 and then declined to 20/200 (p = 0.001) with an average follow-up time of 30.2 months. There was no significant VA change after the initial loss with reabsorption. The average initial lesion size of GA was 0.987 mm(2) with an average growth rate of 0.274 mm/year. CONCLUSIONS: This study longitudinally examined GA growth rate in patients with reabsorbed PEDs. These patients started with a drusenoid or serous PED, had a dramatic reduction in vision and GA that occurred in place of the PED. These GA lesions have a slower growth rate and a smaller area of onset compared to rates previously reported in the literature. They do not show significant VA change after reabsorption. As we have entered the era of GA therapy, these patients may not benefit from current treatments. |
format | Online Article Text |
id | pubmed-10228064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102280642023-05-31 Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study Peng, Enoch T. Adrean, Sean D. BMC Ophthalmol Research Article BACKGROUND: To describe the occurrence, rate of geographic atrophy (GA) expansion, and changes in visual acuity (VA) after reabsorption of subfoveal pigment epithelial detachments (PED). METHODS: Included patients had reabsorption of a PED followed by GA. Patients underwent clinical examination with SD-OCT. Images were classified by size with grading occurring post reabsorption. VA was recorded pre-reabsorption, post-reabsorption, and over time. RESULTS: The average age of the cohort, consisting of 22 eyes from 19 participants, was 86.9 years at reabsorption. Prior to reabsorption, the VA was 20/80 and then declined to 20/200 (p = 0.001) with an average follow-up time of 30.2 months. There was no significant VA change after the initial loss with reabsorption. The average initial lesion size of GA was 0.987 mm(2) with an average growth rate of 0.274 mm/year. CONCLUSIONS: This study longitudinally examined GA growth rate in patients with reabsorbed PEDs. These patients started with a drusenoid or serous PED, had a dramatic reduction in vision and GA that occurred in place of the PED. These GA lesions have a slower growth rate and a smaller area of onset compared to rates previously reported in the literature. They do not show significant VA change after reabsorption. As we have entered the era of GA therapy, these patients may not benefit from current treatments. BioMed Central 2023-05-30 /pmc/articles/PMC10228064/ /pubmed/37254103 http://dx.doi.org/10.1186/s12886-023-02993-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Peng, Enoch T. Adrean, Sean D. Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study |
title | Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study |
title_full | Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study |
title_fullStr | Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study |
title_full_unstemmed | Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study |
title_short | Geographic Atrophy after Reabsorption of Pigment Epithelial Detachment (GARPED) study |
title_sort | geographic atrophy after reabsorption of pigment epithelial detachment (garped) study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228064/ https://www.ncbi.nlm.nih.gov/pubmed/37254103 http://dx.doi.org/10.1186/s12886-023-02993-3 |
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