Pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice

We present the case of a 71-year-old female treated for infective endocarditis with flucloxacillin and paracetamol. Her clinical course became complicated by a blood-gas demonstrating a raised anion gap metabolic acidosis. The patient was diagnosed with pyroglutamic metabolic acidosis. This is a rar...

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Detalles Bibliográficos
Autores principales: Duncan, A, McDermott, H, Corcoran, S, Devine, C, Barry, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228107/
https://www.ncbi.nlm.nih.gov/pubmed/37260733
http://dx.doi.org/10.1093/omcr/omad048
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author Duncan, A
McDermott, H
Corcoran, S
Devine, C
Barry, C
author_facet Duncan, A
McDermott, H
Corcoran, S
Devine, C
Barry, C
author_sort Duncan, A
collection PubMed
description We present the case of a 71-year-old female treated for infective endocarditis with flucloxacillin and paracetamol. Her clinical course became complicated by a blood-gas demonstrating a raised anion gap metabolic acidosis. The patient was diagnosed with pyroglutamic metabolic acidosis. This is a rare interaction between high dose flucloxacillin and paracetamol, and is an important complication to recognize.
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spelling pubmed-102281072023-05-31 Pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice Duncan, A McDermott, H Corcoran, S Devine, C Barry, C Oxf Med Case Reports Case Report We present the case of a 71-year-old female treated for infective endocarditis with flucloxacillin and paracetamol. Her clinical course became complicated by a blood-gas demonstrating a raised anion gap metabolic acidosis. The patient was diagnosed with pyroglutamic metabolic acidosis. This is a rare interaction between high dose flucloxacillin and paracetamol, and is an important complication to recognize. Oxford University Press 2023-05-30 /pmc/articles/PMC10228107/ /pubmed/37260733 http://dx.doi.org/10.1093/omcr/omad048 Text en © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Duncan, A
McDermott, H
Corcoran, S
Devine, C
Barry, C
Pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice
title Pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice
title_full Pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice
title_fullStr Pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice
title_full_unstemmed Pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice
title_short Pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice
title_sort pyroglutamic acidosis caused by the combination of two common medicines prescribed in everyday practice
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228107/
https://www.ncbi.nlm.nih.gov/pubmed/37260733
http://dx.doi.org/10.1093/omcr/omad048
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