Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain

The pharmacological management of nonspecific chronic low back pain (NCLBP) aims to restore patients’ daily activities and improve their quality of life. The management of NCLBP is not well codified and extremely heterogeneous, and residual symptoms are common. Pharmacological management should be c...

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Autores principales: Migliorini, Filippo, Vaishya, Raju, Pappalardo, Gaetano, Schneider, Marco, Bell, Andreas, Maffulli, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228138/
https://www.ncbi.nlm.nih.gov/pubmed/37254090
http://dx.doi.org/10.1186/s12891-023-06537-0
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author Migliorini, Filippo
Vaishya, Raju
Pappalardo, Gaetano
Schneider, Marco
Bell, Andreas
Maffulli, Nicola
author_facet Migliorini, Filippo
Vaishya, Raju
Pappalardo, Gaetano
Schneider, Marco
Bell, Andreas
Maffulli, Nicola
author_sort Migliorini, Filippo
collection PubMed
description The pharmacological management of nonspecific chronic low back pain (NCLBP) aims to restore patients’ daily activities and improve their quality of life. The management of NCLBP is not well codified and extremely heterogeneous, and residual symptoms are common. Pharmacological management should be considered as co-adjuvant to non-pharmacological therapy, and should be guided by the symptoms reported by the patients. Depending on the individual severity of NCLPB, pharmacological management may range from nonopioid to opioid analgesics. It is important to identify patients with generalized sensory hypersensitivity, who may benefit from dedicated therapy. This article provides an evidence-based overview of the principles of pharmacological management of NCLPB.
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spelling pubmed-102281382023-05-31 Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain Migliorini, Filippo Vaishya, Raju Pappalardo, Gaetano Schneider, Marco Bell, Andreas Maffulli, Nicola BMC Musculoskelet Disord Research The pharmacological management of nonspecific chronic low back pain (NCLBP) aims to restore patients’ daily activities and improve their quality of life. The management of NCLBP is not well codified and extremely heterogeneous, and residual symptoms are common. Pharmacological management should be considered as co-adjuvant to non-pharmacological therapy, and should be guided by the symptoms reported by the patients. Depending on the individual severity of NCLPB, pharmacological management may range from nonopioid to opioid analgesics. It is important to identify patients with generalized sensory hypersensitivity, who may benefit from dedicated therapy. This article provides an evidence-based overview of the principles of pharmacological management of NCLPB. BioMed Central 2023-05-30 /pmc/articles/PMC10228138/ /pubmed/37254090 http://dx.doi.org/10.1186/s12891-023-06537-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Migliorini, Filippo
Vaishya, Raju
Pappalardo, Gaetano
Schneider, Marco
Bell, Andreas
Maffulli, Nicola
Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain
title Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain
title_full Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain
title_fullStr Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain
title_full_unstemmed Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain
title_short Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain
title_sort between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228138/
https://www.ncbi.nlm.nih.gov/pubmed/37254090
http://dx.doi.org/10.1186/s12891-023-06537-0
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