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Early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy

Type 1 diabetes (T1D) is mainly a disease of children and young adults. The onset of disease is associated with 3 classical symptoms: polydipsia, polyphagia, and polyuria. Hyperglycaemia is the main and primary metabolic disorder in T1D. One of the complications developing as a result of microangiop...

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Autores principales: Burlaka, Ievgeniia, Maidannyk, Vitaliy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228199/
https://www.ncbi.nlm.nih.gov/pubmed/34743502
http://dx.doi.org/10.5114/pedm.2021.107720
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author Burlaka, Ievgeniia
Maidannyk, Vitaliy
author_facet Burlaka, Ievgeniia
Maidannyk, Vitaliy
author_sort Burlaka, Ievgeniia
collection PubMed
description Type 1 diabetes (T1D) is mainly a disease of children and young adults. The onset of disease is associated with 3 classical symptoms: polydipsia, polyphagia, and polyuria. Hyperglycaemia is the main and primary metabolic disorder in T1D. One of the complications developing as a result of microangiopathy is diabetic nephropathy (DN). Additionally, diabetes remains the most common reason for progressing to end-stage renal disease (ESRD). The aim of the study was to evaluate the most initial metabolic and functional disorders in diabetic children and children with DN. The study involved 76 children with T1D and diabetic nephropathy (aged 3 to 17 years). The levels of ET-1 measured using ELISA assay and ratio of lipid oxidation measured spectrophotometrically. Main clinical parameters (blood pressure, glycaemia, albuminuria, creatininaemia, HbA(1C), cholesterol levels) were measured using conventional methods available in Clinical Paediatric Hospital No. 6 (Kyiv, Ukraine). The glomerular filtration rate (GFR) was calculated using the Schwartz formula. Patterns of the BP changes, kidney function impairment, ET-level, and metabolic and functional disorders in children with T1D and DN were found.
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spelling pubmed-102281992023-06-05 Early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy Burlaka, Ievgeniia Maidannyk, Vitaliy Pediatr Endocrinol Diabetes Metab Original paper | Praca oryginalna Type 1 diabetes (T1D) is mainly a disease of children and young adults. The onset of disease is associated with 3 classical symptoms: polydipsia, polyphagia, and polyuria. Hyperglycaemia is the main and primary metabolic disorder in T1D. One of the complications developing as a result of microangiopathy is diabetic nephropathy (DN). Additionally, diabetes remains the most common reason for progressing to end-stage renal disease (ESRD). The aim of the study was to evaluate the most initial metabolic and functional disorders in diabetic children and children with DN. The study involved 76 children with T1D and diabetic nephropathy (aged 3 to 17 years). The levels of ET-1 measured using ELISA assay and ratio of lipid oxidation measured spectrophotometrically. Main clinical parameters (blood pressure, glycaemia, albuminuria, creatininaemia, HbA(1C), cholesterol levels) were measured using conventional methods available in Clinical Paediatric Hospital No. 6 (Kyiv, Ukraine). The glomerular filtration rate (GFR) was calculated using the Schwartz formula. Patterns of the BP changes, kidney function impairment, ET-level, and metabolic and functional disorders in children with T1D and DN were found. Termedia Publishing House 2021-09-30 2021-09 /pmc/articles/PMC10228199/ /pubmed/34743502 http://dx.doi.org/10.5114/pedm.2021.107720 Text en Copyright © Polish Society of Pediatric Endocrinology and Diabetes https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), allowing third parties to download and share its works but not commercially purposes or to create derivative works.
spellingShingle Original paper | Praca oryginalna
Burlaka, Ievgeniia
Maidannyk, Vitaliy
Early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy
title Early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy
title_full Early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy
title_fullStr Early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy
title_full_unstemmed Early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy
title_short Early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy
title_sort early functional and metabolic disorders in children with type 1 diabetes mellitus and diabetic nephropathy
topic Original paper | Praca oryginalna
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228199/
https://www.ncbi.nlm.nih.gov/pubmed/34743502
http://dx.doi.org/10.5114/pedm.2021.107720
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