New-Onset Crohn's Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn's Disease

Patients with autoimmune conditions show a high expression of proinflammatory cytokines including interleukin (IL)-17. While IL-17 inhibitors have demonstrated efficacy in managing autoimmune disorders, rare instances of de novo or exacerbated inflammatory bowel disease (IBD) have been reported. The...

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Detalles Bibliográficos
Autores principales: Khouri, Anas, Moreno, Cesar, Niland, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228216/
https://www.ncbi.nlm.nih.gov/pubmed/37260537
http://dx.doi.org/10.1155/2023/1769290
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author Khouri, Anas
Moreno, Cesar
Niland, Benjamin
author_facet Khouri, Anas
Moreno, Cesar
Niland, Benjamin
author_sort Khouri, Anas
collection PubMed
description Patients with autoimmune conditions show a high expression of proinflammatory cytokines including interleukin (IL)-17. While IL-17 inhibitors have demonstrated efficacy in managing autoimmune disorders, rare instances of de novo or exacerbated inflammatory bowel disease (IBD) have been reported. The factors that affect the onset and severity remain unclear. Here, we present a case of a 38-year-old female who developed manifestations of Crohn's disease within 1 month of initiating secukinumab treatment for psoriatic arthritis, in addition to a review of the role of IL-17 in the pathophysiology of Crohn's disease.
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spelling pubmed-102282162023-05-31 New-Onset Crohn's Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn's Disease Khouri, Anas Moreno, Cesar Niland, Benjamin Case Rep Gastrointest Med Case Report Patients with autoimmune conditions show a high expression of proinflammatory cytokines including interleukin (IL)-17. While IL-17 inhibitors have demonstrated efficacy in managing autoimmune disorders, rare instances of de novo or exacerbated inflammatory bowel disease (IBD) have been reported. The factors that affect the onset and severity remain unclear. Here, we present a case of a 38-year-old female who developed manifestations of Crohn's disease within 1 month of initiating secukinumab treatment for psoriatic arthritis, in addition to a review of the role of IL-17 in the pathophysiology of Crohn's disease. Hindawi 2023-05-22 /pmc/articles/PMC10228216/ /pubmed/37260537 http://dx.doi.org/10.1155/2023/1769290 Text en Copyright © 2023 Anas Khouri et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Khouri, Anas
Moreno, Cesar
Niland, Benjamin
New-Onset Crohn's Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn's Disease
title New-Onset Crohn's Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn's Disease
title_full New-Onset Crohn's Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn's Disease
title_fullStr New-Onset Crohn's Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn's Disease
title_full_unstemmed New-Onset Crohn's Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn's Disease
title_short New-Onset Crohn's Disease following Initiation of Secukinumab: A Case Report and Review of the Role of IL-17 in the Pathogenesis of Crohn's Disease
title_sort new-onset crohn's disease following initiation of secukinumab: a case report and review of the role of il-17 in the pathogenesis of crohn's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228216/
https://www.ncbi.nlm.nih.gov/pubmed/37260537
http://dx.doi.org/10.1155/2023/1769290
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