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Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction

The incidence of acute myocardial infarction (AMI) in hemodialysis (HD) patients is high and the prognosis is extremely poor. However, the potential connection between HD and AMI, and its regulatory mechanisms remain unclear. In this study, the gene expression profiles of HD (GSE15072) and AMI (GSE6...

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Autores principales: Yang, Yue, Jiao, Yuan-yuan, Zhang, Zheng, Zhuo, Li, Li, Wen-ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228304/
https://www.ncbi.nlm.nih.gov/pubmed/37246754
http://dx.doi.org/10.1080/0886022X.2023.2216307
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author Yang, Yue
Jiao, Yuan-yuan
Zhang, Zheng
Zhuo, Li
Li, Wen-ge
author_facet Yang, Yue
Jiao, Yuan-yuan
Zhang, Zheng
Zhuo, Li
Li, Wen-ge
author_sort Yang, Yue
collection PubMed
description The incidence of acute myocardial infarction (AMI) in hemodialysis (HD) patients is high and the prognosis is extremely poor. However, the potential connection between HD and AMI, and its regulatory mechanisms remain unclear. In this study, the gene expression profiles of HD (GSE15072) and AMI (GSE66360) were downloaded from the Gene Expression Omnibus database, common differentially expressed genes (DEGs) were obtained using the limma R package, the biological functions were analyzed according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, machine learning was conducted to identify hub genes. Receiver operating characteristic curves and gene set enrichment analyses were used to explore the characters and biological function of hub genes, networks were used for candidate identification of transcription factor (TF), microRNA (miRNA), and drug. After a total of 255 common DEGs were selected, GO and KEGG analyses indicated that neutrophil extracellular trap (NET) may be a potential connection between HD and AMI, LILRB2, S100A12, CYBB, ITGAM, and PPIF were finally identified as hub genes. The area under curve of LILRB2, S100A12, and PPIF was higher than 0.8 in both datasets. Networks show the relationship between hub genes, TF, and miRNA, also the relationship between potential drugs and protein. In conclusion, NETs may be the potential connection between AMI and HD. The potential hub gene, signaling pathways, and drugs provided by this study may contribute to future AMI prevention and intervention in HD patients.
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spelling pubmed-102283042023-05-31 Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction Yang, Yue Jiao, Yuan-yuan Zhang, Zheng Zhuo, Li Li, Wen-ge Ren Fail Laboratory Study The incidence of acute myocardial infarction (AMI) in hemodialysis (HD) patients is high and the prognosis is extremely poor. However, the potential connection between HD and AMI, and its regulatory mechanisms remain unclear. In this study, the gene expression profiles of HD (GSE15072) and AMI (GSE66360) were downloaded from the Gene Expression Omnibus database, common differentially expressed genes (DEGs) were obtained using the limma R package, the biological functions were analyzed according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, machine learning was conducted to identify hub genes. Receiver operating characteristic curves and gene set enrichment analyses were used to explore the characters and biological function of hub genes, networks were used for candidate identification of transcription factor (TF), microRNA (miRNA), and drug. After a total of 255 common DEGs were selected, GO and KEGG analyses indicated that neutrophil extracellular trap (NET) may be a potential connection between HD and AMI, LILRB2, S100A12, CYBB, ITGAM, and PPIF were finally identified as hub genes. The area under curve of LILRB2, S100A12, and PPIF was higher than 0.8 in both datasets. Networks show the relationship between hub genes, TF, and miRNA, also the relationship between potential drugs and protein. In conclusion, NETs may be the potential connection between AMI and HD. The potential hub gene, signaling pathways, and drugs provided by this study may contribute to future AMI prevention and intervention in HD patients. Taylor & Francis 2023-05-29 /pmc/articles/PMC10228304/ /pubmed/37246754 http://dx.doi.org/10.1080/0886022X.2023.2216307 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Laboratory Study
Yang, Yue
Jiao, Yuan-yuan
Zhang, Zheng
Zhuo, Li
Li, Wen-ge
Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction
title Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction
title_full Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction
title_fullStr Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction
title_full_unstemmed Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction
title_short Neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction
title_sort neutrophil extracellular trap is an important connection between hemodialysis and acute myocardial infarction
topic Laboratory Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228304/
https://www.ncbi.nlm.nih.gov/pubmed/37246754
http://dx.doi.org/10.1080/0886022X.2023.2216307
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