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Surface-modified Ti(3)C(2) MXene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion

In the field of bone tissue engineering, the practical application of growth factors is limited by various factors such as systemic toxicity, instability, and the potential to induce inflammation. To circumvent these limitations, the use of physical signals, such as thermal stimulation, to regulate...

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Detalles Bibliográficos
Autores principales: Zhang, Jiebing, Tang, Shuang, Ding, Ning, Ma, Ping, Zhang, Zutai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228341/
https://www.ncbi.nlm.nih.gov/pubmed/37260501
http://dx.doi.org/10.1039/d3na00187c
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author Zhang, Jiebing
Tang, Shuang
Ding, Ning
Ma, Ping
Zhang, Zutai
author_facet Zhang, Jiebing
Tang, Shuang
Ding, Ning
Ma, Ping
Zhang, Zutai
author_sort Zhang, Jiebing
collection PubMed
description In the field of bone tissue engineering, the practical application of growth factors is limited by various factors such as systemic toxicity, instability, and the potential to induce inflammation. To circumvent these limitations, the use of physical signals, such as thermal stimulation, to regulate stem cells has been proposed as a promising alternative. The present study aims to investigate the potential of the two-dimensional nanomaterial Ti(3)C(2) MXene, which exhibits unique photothermal properties, to induce osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) via photothermal conversion. Surface modification of Ti(3)C(2) MXene nanosheets with PVP (Ti(3)C(2)–PVP) was employed to enhance their colloidal stability in physiological solutions. Characterization and cellular experiments showed that Ti(3)C(2)–PVP nanosheets have favorable photothermal properties and biocompatibility. Our study demonstrated that the induction of photothermal stimulation by co-culturing Ti(3)C(2)–PVP nanosheets with BMSCs and subsequent irradiation with 808 nm NIR significantly promoted cell proliferation, adhesion and osteogenic differentiation of BMSCs. In conclusion, the results of this study suggest that Ti(3)C(2)–PVP is a promising material for bone tissue engineering applications as it can modulate the cellular functions of BMSCs through photothermal conversion.
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spelling pubmed-102283412023-05-31 Surface-modified Ti(3)C(2) MXene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion Zhang, Jiebing Tang, Shuang Ding, Ning Ma, Ping Zhang, Zutai Nanoscale Adv Chemistry In the field of bone tissue engineering, the practical application of growth factors is limited by various factors such as systemic toxicity, instability, and the potential to induce inflammation. To circumvent these limitations, the use of physical signals, such as thermal stimulation, to regulate stem cells has been proposed as a promising alternative. The present study aims to investigate the potential of the two-dimensional nanomaterial Ti(3)C(2) MXene, which exhibits unique photothermal properties, to induce osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) via photothermal conversion. Surface modification of Ti(3)C(2) MXene nanosheets with PVP (Ti(3)C(2)–PVP) was employed to enhance their colloidal stability in physiological solutions. Characterization and cellular experiments showed that Ti(3)C(2)–PVP nanosheets have favorable photothermal properties and biocompatibility. Our study demonstrated that the induction of photothermal stimulation by co-culturing Ti(3)C(2)–PVP nanosheets with BMSCs and subsequent irradiation with 808 nm NIR significantly promoted cell proliferation, adhesion and osteogenic differentiation of BMSCs. In conclusion, the results of this study suggest that Ti(3)C(2)–PVP is a promising material for bone tissue engineering applications as it can modulate the cellular functions of BMSCs through photothermal conversion. RSC 2023-05-09 /pmc/articles/PMC10228341/ /pubmed/37260501 http://dx.doi.org/10.1039/d3na00187c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Jiebing
Tang, Shuang
Ding, Ning
Ma, Ping
Zhang, Zutai
Surface-modified Ti(3)C(2) MXene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion
title Surface-modified Ti(3)C(2) MXene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion
title_full Surface-modified Ti(3)C(2) MXene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion
title_fullStr Surface-modified Ti(3)C(2) MXene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion
title_full_unstemmed Surface-modified Ti(3)C(2) MXene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion
title_short Surface-modified Ti(3)C(2) MXene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion
title_sort surface-modified ti(3)c(2) mxene nanosheets for mesenchymal stem cell osteogenic differentiation via photothermal conversion
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228341/
https://www.ncbi.nlm.nih.gov/pubmed/37260501
http://dx.doi.org/10.1039/d3na00187c
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