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hACE2-Induced Allosteric Activation in SARS-CoV versus SARS-CoV-2 Spike Assemblies Revealed by Structural Dynamics

[Image: see text] SARS-CoV and SARS-CoV-2 cell entry begins when spike glycoprotein (S) docks with the human ACE2 (hACE2) receptor. While the two coronaviruses share a common receptor and architecture of S, they exhibit differences in interactions with hACE2 as well as differences in proteolytic pro...

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Detalles Bibliográficos
Autores principales:	Chen, Chengbo, Zhu, Richard, Hodge, Edgar A., Díaz-Salinas, Marco A., Nguyen, Adam, Munro, James B., Lee, Kelly K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228703/ https://www.ncbi.nlm.nih.gov/pubmed/37166130 http://dx.doi.org/10.1021/acsinfecdis.3c00010

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