Cargando…

Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by inhibiting hepatic oxidative stress and inflammation via the SREBP-1-c/ PPARα-NF-κB/IR-S2 signaling pathway

Introduction: Nonalcoholic fatty liver disease (NAFLD) is a chronic disease characterized by fat deposits in liver cells, which can lead to hepatitis and fibrosis. This study attempted to explore the protective effect of vitamin D3 (VitD) against NAFLD. Methods: Adult male albino rats were randomize...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reda, Doha, Elshopakey, Gehad E., Albukhari, Talat A., Almehmadi, Samah J., Refaat, Bassem, Risha, Engy F., Mahgoub, Hebatallah A., El-Boshy, Mohamed E., Abdelhamid, Fatma M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228732/ https://www.ncbi.nlm.nih.gov/pubmed/37261280 http://dx.doi.org/10.3389/fphar.2023.1164512

Ejemplares similares

Hepatoprotective and Neuroprotective Effects of Naringenin against Lead-Induced Oxidative Stress, Inflammation, and Apoptosis in Rats
por: Mansour, Lubna A. H., et al.
Publicado: (2023)

Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role of Oxidative Stress, Inflammation, and Insulin Resistance
por: Reda, Doha, et al.
Publicado: (2022)

Antioxidative and Anti-Inflammatory Protective Effects of β-Caryophyllene against Amikacin-Induced Nephrotoxicity in Rat by Regulating the Nrf2/AMPK/AKT and NF-κB/TGF-β/KIM-1 Molecular Pathways
por: Rajab, Bodour S., et al.
Publicado: (2022)

Vitamin D Ameliorates the Hepatic Oxidative Damage and Fibrotic Effect Caused by Thioacetamide in Rats
por: Megahed, Aya, et al.
Publicado: (2023)

Enhanced renoprotective actions of Paricalcitol and omega-3 fatty acids co-therapy against diabetic nephropathy in rat
por: El-Boshy, Mohamed, et al.
Publicado: (2021)

Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats
por: Aboraya, Dina M., et al.
Publicado: (2022)

Effect of Withania somnifera Extracts on Some Selective Biochemical, Hematological, and Immunological Parameters in Guinea Pigs Experimental Infected with E. coli
por: El-Boshy, Mohamed El-Sayed, et al.
Publicado: (2013)

Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats
por: Elshopakey, Gehad E., et al.
Publicado: (2021)

Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis
por: Kawamura, Satoshi, et al.
Publicado: (2022)

Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats
por: BaSalamah, Mohammad A., et al.
Publicado: (2018)

Lipid Regulators during Atherogenesis: Expression of LXR, PPAR, and SREBP mRNA in the Human Aorta
por: Shchelkunova, Tatyana A., et al.
Publicado: (2013)

Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2
por: Wang, Siying, et al.
Publicado: (2023)

Regulation of FADS2 transcription by SREBP-1 and PPAR-α influences LC-PUFA biosynthesis in fish
por: Dong, Xiaojing, et al.
Publicado: (2017)

Gemfibrozil reduces lipid accumulation in SMMC-7721 cells via the involvement of PPARα and SREBP1
por: Zhang, Xiaonan, et al.
Publicado: (2019)

Update on Pparγ and Nonalcoholic Fatty Liver Disease
por: Ables, Gene P.
Publicado: (2012)

PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting
por: Lee, Jae-Ho, et al.
Publicado: (2017)

Protective role of adjuvant and potassium permanganate on oxidative stress response of Nile tilapia (Oreochromis niloticus) challenged with Saprolegnia ferax
por: Zahran, Eman, et al.
Publicado: (2013)

PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A
por: LU, YU, et al.
Publicado: (2023)

Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c
por: Tang, Kairui, et al.
Publicado: (2020)

Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens
por: Zhang, Lijun, et al.
Publicado: (2015)

The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation
por: Gu, Hyemin, et al.
Publicado: (2022)

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway
por: He, Jinbiao, et al.
Publicado: (2022)

Therapeutic Targeting of Nonalcoholic Fatty Liver Disease by Downregulating SREBP-1C Expression via AMPK-KLF10 Axis
por: Chen, Yu-Chi, et al.
Publicado: (2021)

TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis
por: Zhang, Yanmei, et al.
Publicado: (2021)

Skeletal muscle insulin resistance in hamsters with diabetes developed from obesity is involved in abnormal skeletal muscle LXR, PPAR and SREBP expression
por: LI, GUO-SHENG, et al.
Publicado: (2016)

Corrigendum: Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway
por: He, Jinbiao, et al.
Publicado: (2023)

Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells
por: Yang, Nian, et al.
Publicado: (2019)

Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling
por: Hu, Xiao-Qian, et al.
Publicado: (2010)

Octyl gallate induces hepatic steatosis in HepG2 cells through the regulation of SREBP-1c and PPAR-gamma gene expression
por: Lima, Kelly Goulart, et al.
Publicado: (2020)

Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation
por: Miyata, Shingo, et al.
Publicado: (2022)

Key events in cancer: Dysregulation of SREBPs
por: Li, Yunkuo, et al.
Publicado: (2023)

The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α
por: Ren, Tingting, et al.
Publicado: (2017)

Chronic Oleoylethanolamide Treatment Decreases Hepatic Triacylglycerol Level in Rat Liver by a PPARγ/SREBP-Mediated Suppression of Fatty Acid and Triacylglycerol Synthesis
por: Romano, Adele, et al.
Publicado: (2021)

Genistein Attenuates Nonalcoholic Steatohepatitis and Increases Hepatic PPARγ in a Rat Model
por: Susutlertpanya, Warinda, et al.
Publicado: (2015)

Role of Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease
por: Chen, Changxi, et al.
Publicado: (2022)

PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)
por: Todisco, Simona, et al.
Publicado: (2022)

Role of activins in embryo implantation and diagnosis of ectopic pregnancy: a review
por: Refaat, Bassem
Publicado: (2014)

Therapeutic Potency of Ginger, Garlic, and Pomegranate Extracts Against Cryptosporidium parvum-Mediated Gastro-Splenic Damage in Mice
por: EL-Shewehy, Dina M. M., et al.
Publicado: (2022)

Coenzyme Q10-Loaded Albumin Nanoparticles Protect against Redox Imbalance and Inflammatory, Apoptotic, and Histopathological Alterations in Mercuric Chloride-Induced Hepatorenal Toxicity in Rats
por: Ramadan, Shimaa S., et al.
Publicado: (2023)

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
por: Rong, Shunxing, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_onauh30d7dnmsb954aqnvrf4pi