Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

BACKGROUND: Poor prognosis in colon cancer is associated with a high content of cancer-associated fibroblasts (CAFs) and an immunosuppressive tumor microenvironment. The relationship between these two features is incompletely understood. Here, we aimed to generate a model system for studying the int...

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Detalles Bibliográficos
Autores principales: Strating, Esther, Verhagen, Mathijs P., Wensink, Emerens, Dünnebach, Ester, Wijler, Liza, Aranguren, Itziar, De la Cruz, Alberto Sanchez, Peters, Niek A., Hageman, Joris H., van der Net, Mirjam M. C., van Schelven, Susanne, Laoukili, Jamila, Fodde, Riccardo, Roodhart, Jeanine, Nierkens, Stefan, Snippert, Hugo, Gloerich, Martijn, Rinkes, Inne Borel, Elias, Sjoerd G., Kranenburg, Onno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228738/
https://www.ncbi.nlm.nih.gov/pubmed/37261365
http://dx.doi.org/10.3389/fimmu.2023.1053920

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