Identification of CDRH3 loops in the B cell receptor repertoire that can be engaged by candidate immunogens

A major goal for the development of vaccines against rapidly mutating viruses, such as influenza or HIV, is to elicit antibodies with broad neutralization capacity. However, B cell precursors capable of maturing into broadly neutralizing antibodies (bnAbs) can be rare in the immune repertoire. Due t...

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Detalles Bibliográficos
Autores principales: Swanson, Olivia, Martin Beem, Joshua S., Rhodes, Brianna, Wang, Avivah, Barr, Maggie, Chen, Haiyan, Parks, Robert, Saunders, Kevin O., Haynes, Barton F., Wiehe, Kevin, Azoitei, Mihai L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228794/
https://www.ncbi.nlm.nih.gov/pubmed/37196027
http://dx.doi.org/10.1371/journal.ppat.1011401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228794/
https://www.ncbi.nlm.nih.gov/pubmed/37196027
http://dx.doi.org/10.1371/journal.ppat.1011401

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