Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2

SARS-CoV Spike (S) protein shares considerable homology with SARS-CoV-2 S, especially in the conserved S2 subunit (S2). S protein mediates coronavirus receptor binding and membrane fusion, and the latter activity can greatly influence coronavirus infection. We observed that SARS-CoV S is less effect...

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Detalles Bibliográficos
Autores principales: Ma, Yong, Li, Pengbin, Hu, Yunqi, Qiu, Tianyi, Wang, Lixiang, Lu, Hongjie, Lv, Kexin, Xu, Mengxin, Zhuang, Jiaxin, Liu, Xue, He, Suhua, He, Bing, Liu, Shuning, Liu, Lin, Wang, Yuanyuan, Yue, Xinyu, Zhai, Yanmei, Luo, Wanyu, Mai, Haoting, Kuang, Yu, Chen, Shifeng, Ye, Feng, Zhou, Na, Zhao, Wenjing, Chen, Jun, Chen, Shoudeng, Xiong, Xiaoli, Shi, Mang, Pan, Ji-An, Chen, Yao-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228797/
https://www.ncbi.nlm.nih.gov/pubmed/37196033
http://dx.doi.org/10.1371/journal.ppat.1011123

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