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Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring
Fetal Alcohol Spectrum Disorder (FASD) comprises a group of neurodevelopmental deficits caused by alcohol exposure during pregnancy. Clinical studies suggest that while the male progeny experiences serious neurodevelopmental defects, female patients have more severe cognitive, social, and affective...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229070/ https://www.ncbi.nlm.nih.gov/pubmed/37260840 http://dx.doi.org/10.3389/fnins.2023.1160185 |
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author | Bariselli, Sebastiano Reuveni, Noa Westcott, Nina Mateo, Yolanda Lovinger, David M. |
author_facet | Bariselli, Sebastiano Reuveni, Noa Westcott, Nina Mateo, Yolanda Lovinger, David M. |
author_sort | Bariselli, Sebastiano |
collection | PubMed |
description | Fetal Alcohol Spectrum Disorder (FASD) comprises a group of neurodevelopmental deficits caused by alcohol exposure during pregnancy. Clinical studies suggest that while the male progeny experiences serious neurodevelopmental defects, female patients have more severe cognitive, social, and affective symptoms. Other than sex, dose, frequency, and timing of exposure determine the neurobehavioral outcomes in young and adult progeny. In this regard, human studies indicate that some individuals relapse during late-term gestational periods. In mice, this interval corresponds to the first 10 days after birth (postnatal, P0-P10). In our model of postnatal ethanol exposure (PEE(P0-P10)), we tested whether adult female and male offspring show deficits in sociability, anxiety-like, reward consumption, and action-outcome associations. We report that female PEE(P0-P10) offspring have mild social impairments and altered extinction of operant responding in the absence of anxiety-like traits and reward consumption defects. None of these deficits were detected in the male PEE(P0-P10) offspring. Our data provide novel information on sex-specific neurobehavioral outcomes of postnatal ethanol exposure in female adult offspring. |
format | Online Article Text |
id | pubmed-10229070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102290702023-05-31 Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring Bariselli, Sebastiano Reuveni, Noa Westcott, Nina Mateo, Yolanda Lovinger, David M. Front Neurosci Neuroscience Fetal Alcohol Spectrum Disorder (FASD) comprises a group of neurodevelopmental deficits caused by alcohol exposure during pregnancy. Clinical studies suggest that while the male progeny experiences serious neurodevelopmental defects, female patients have more severe cognitive, social, and affective symptoms. Other than sex, dose, frequency, and timing of exposure determine the neurobehavioral outcomes in young and adult progeny. In this regard, human studies indicate that some individuals relapse during late-term gestational periods. In mice, this interval corresponds to the first 10 days after birth (postnatal, P0-P10). In our model of postnatal ethanol exposure (PEE(P0-P10)), we tested whether adult female and male offspring show deficits in sociability, anxiety-like, reward consumption, and action-outcome associations. We report that female PEE(P0-P10) offspring have mild social impairments and altered extinction of operant responding in the absence of anxiety-like traits and reward consumption defects. None of these deficits were detected in the male PEE(P0-P10) offspring. Our data provide novel information on sex-specific neurobehavioral outcomes of postnatal ethanol exposure in female adult offspring. Frontiers Media S.A. 2023-05-16 /pmc/articles/PMC10229070/ /pubmed/37260840 http://dx.doi.org/10.3389/fnins.2023.1160185 Text en Copyright © 2023 Bariselli, Reuveni, Westcott, Mateo and Lovinger. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Bariselli, Sebastiano Reuveni, Noa Westcott, Nina Mateo, Yolanda Lovinger, David M. Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring |
title | Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring |
title_full | Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring |
title_fullStr | Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring |
title_full_unstemmed | Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring |
title_short | Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring |
title_sort | postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229070/ https://www.ncbi.nlm.nih.gov/pubmed/37260840 http://dx.doi.org/10.3389/fnins.2023.1160185 |
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