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Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease

In Alzheimer's disease (AD) patients, low levels of physical fitness (PF) and cognitive status are associated with high rates of depression. However, this condition can be improved through physical training. OBJECTIVE: The aim of the present study was to investigate the effect of multimodal exe...

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Autores principales: Haghighi, Amir Hossein, Barzoei, Masoud, Kakhak, Seyed Alireza Hosseini, Budini, Francesco, Shahrabadi, Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229082/
https://www.ncbi.nlm.nih.gov/pubmed/37261252
http://dx.doi.org/10.1590/1980-5764-DN-2022-0008
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author Haghighi, Amir Hossein
Barzoei, Masoud
Kakhak, Seyed Alireza Hosseini
Budini, Francesco
Shahrabadi, Hadi
author_facet Haghighi, Amir Hossein
Barzoei, Masoud
Kakhak, Seyed Alireza Hosseini
Budini, Francesco
Shahrabadi, Hadi
author_sort Haghighi, Amir Hossein
collection PubMed
description In Alzheimer's disease (AD) patients, low levels of physical fitness (PF) and cognitive status are associated with high rates of depression. However, this condition can be improved through physical training. OBJECTIVE: The aim of the present study was to investigate the effect of multimodal exercise training (MET) on aerobic endurance, muscular strength, agility, dynamic balance, cognitive status, and depressive symptoms in men with mild-to-moderate AD. METHODS: A total of 25 elderly men with a diagnosis of mild-to-moderate AD were randomly categorized into an MET or a control group. The subjects in the MET group participated in a 12-week, three sessions per week MET program that included resistance, balance, and aerobic exercises. While the participants in the control group did not perform any regular exercise training during this period. Patients’ cognitive status and depressive symptoms were assessed by Mini-Mental State Examination and the Geriatric Depression Scale-15 (GDS-15) questionnaires. PF indicators such as aerobic endurance, muscular strength, agility, and dynamic balance, as well as cognitive status and depressive symptoms, were taken from all the subjects before and after MET. RESULTS: The participants in the MET group improved handgrip, upper and lower body strength, agility, dynamic balance, and depressive symptoms (p<0.05). The intervention had no significant effect on aerobic endurance and cognitive status (p>0.05). CONCLUSIONS: MET is an effective strategy to improve muscular strength, agility, dynamic balance, and depressive symptoms in men with mild-to-moderate AD. It is recommended for AD patients to engage in this type of exercise to reduce AD complications.
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spelling pubmed-102290822023-05-31 Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease Haghighi, Amir Hossein Barzoei, Masoud Kakhak, Seyed Alireza Hosseini Budini, Francesco Shahrabadi, Hadi Dement Neuropsychol Original Article In Alzheimer's disease (AD) patients, low levels of physical fitness (PF) and cognitive status are associated with high rates of depression. However, this condition can be improved through physical training. OBJECTIVE: The aim of the present study was to investigate the effect of multimodal exercise training (MET) on aerobic endurance, muscular strength, agility, dynamic balance, cognitive status, and depressive symptoms in men with mild-to-moderate AD. METHODS: A total of 25 elderly men with a diagnosis of mild-to-moderate AD were randomly categorized into an MET or a control group. The subjects in the MET group participated in a 12-week, three sessions per week MET program that included resistance, balance, and aerobic exercises. While the participants in the control group did not perform any regular exercise training during this period. Patients’ cognitive status and depressive symptoms were assessed by Mini-Mental State Examination and the Geriatric Depression Scale-15 (GDS-15) questionnaires. PF indicators such as aerobic endurance, muscular strength, agility, and dynamic balance, as well as cognitive status and depressive symptoms, were taken from all the subjects before and after MET. RESULTS: The participants in the MET group improved handgrip, upper and lower body strength, agility, dynamic balance, and depressive symptoms (p<0.05). The intervention had no significant effect on aerobic endurance and cognitive status (p>0.05). CONCLUSIONS: MET is an effective strategy to improve muscular strength, agility, dynamic balance, and depressive symptoms in men with mild-to-moderate AD. It is recommended for AD patients to engage in this type of exercise to reduce AD complications. Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2023-05-29 /pmc/articles/PMC10229082/ /pubmed/37261252 http://dx.doi.org/10.1590/1980-5764-DN-2022-0008 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Haghighi, Amir Hossein
Barzoei, Masoud
Kakhak, Seyed Alireza Hosseini
Budini, Francesco
Shahrabadi, Hadi
Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease
title Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease
title_full Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease
title_fullStr Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease
title_full_unstemmed Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease
title_short Effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in Alzheimer's disease
title_sort effect of multimodal exercise training on physical fitness indices, cognitive status, and depressive symptoms in alzheimer's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229082/
https://www.ncbi.nlm.nih.gov/pubmed/37261252
http://dx.doi.org/10.1590/1980-5764-DN-2022-0008
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