Proton pump inhibitors and dementia: what association?

Several recent studies have suggested an association between proton pump inhibitors and the development of cognitive changes. OBJECTIVE: To assess the existence of this association. METHODS: A comprehensive literature search was conducted including guidelines, meta-analyses, systematic reviews, obse...

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Detalles Bibliográficos
Autores principales: Caetano, Catarina, Veloso, Marta, Borda, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2023
Materias:
View & Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229084/
https://www.ncbi.nlm.nih.gov/pubmed/37261259
http://dx.doi.org/10.1590/1980-5764-DN-2022-0048
Descripción
Sumario:Several recent studies have suggested an association between proton pump inhibitors and the development of cognitive changes. OBJECTIVE: To assess the existence of this association. METHODS: A comprehensive literature search was conducted including guidelines, meta-analyses, systematic reviews, observational and experimental studies published between February 2011 and February 2021. RESULTS: The initial research identified 393 articles, 28 of which were included: 8 systematic reviews, 1 clinical trial, 15 observational studies, 3 case-control studies, and 1 cross-sectional observational study. CONCLUSIONS: Most studies classified with the highest level of evidence found no statistically significant association between the use of proton pump inhibitors and the development of cognitive impairment or dementia.

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