Cargando…

Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho

Beta klotho (KLB) is a fundamental component in fibroblast growth factor receptor (FGFR) signaling as it serves as an obligatory coreceptor for the endocrine hormones fibroblast growth factor 19 (FGF19) and fibroblast growth factor 21 (FGF21). Through the development of FGF19- and FGF21 mimetics, KL...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aaldijk, Alexandra S., Verzijl, Cristy R. C., Jonker, Johan W., Struik, Dicky
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229096/ https://www.ncbi.nlm.nih.gov/pubmed/37260446 http://dx.doi.org/10.3389/fendo.2023.1150222

Ejemplares similares

FGF23 Actions on Target Tissues—With and Without Klotho
por: Richter, Beatrice, et al.
Publicado: (2018)

FGF19 and FGF21 for the Treatment of NASH—Two Sides of the Same Coin? Differential and Overlapping Effects of FGF19 and FGF21 From Mice to Human
por: Henriksson, Emma, et al.
Publicado: (2020)

Editorial: Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease
por: Erben, Reinhold G.
Publicado: (2019)

FGF21 and Cardiac Physiopathology
por: Planavila, Anna, et al.
Publicado: (2015)

FGF21 Requires βklotho to Act In Vivo
por: Adams, Andrew C., et al.
Publicado: (2012)

FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
por: Markan, Kathleen R., et al.
Publicado: (2017)

Metabolic Effects of FGF-21: Thermoregulation and Beyond
por: Ni, Bin, et al.
Publicado: (2015)

PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond
por: Portales-Castillo, Ignacio, et al.
Publicado: (2022)

Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
por: Min, Xiaoshan, et al.
Publicado: (2018)

Stressed Liver and Muscle Call on Adipocytes with FGF21
por: Luo, Yongde, et al.
Publicado: (2013)

The Hepatokine FGF21 Increases the Human Spermatozoa Motility
por: Bourdon, Guillaume, et al.
Publicado: (2022)

Editorial: FGF21 as a therapeutic target for obesity and insulin resistance: from rodent models to humans
por: De Sousa-Coelho, A. L., et al.
Publicado: (2023)

Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD
por: Inagaki, Takeshi
Publicado: (2015)

FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases
por: Itoh, Nobuyuki
Publicado: (2014)

Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine
por: Fang, Han, et al.
Publicado: (2021)

Autocrine FGF1 signaling promotes glucose uptake in adipocytes
por: Nies, Vera J. M., et al.
Publicado: (2022)

FGF19 subfamily members: FGF19 and FGF21
por: Dolegowska, Katarzyna, et al.
Publicado: (2019)

Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy
por: Liu, Qiaoran, et al.
Publicado: (2019)

Osteocytic FGF23 and Its Kidney Function
por: Agoro, Rafiou, et al.
Publicado: (2020)

The roles of FGF21 and GDF15 in mediating the mitochondrial integrated stress response
por: Jena, Jayashree, et al.
Publicado: (2023)

Association of Elevated Plasma FGF21 and Activated FGF21 Signaling in Visceral White Adipose Tissue and Improved Insulin Sensitivity in Gestational Diabetes Mellitus Subtype: A Case-Control Study
por: Wang, Ning, et al.
Publicado: (2021)

Advances in Biological Functions and Clinical Studies of FGF21
por: Lin, Wei, et al.
Publicado: (2021)

The effect of nephrectomy on Klotho, FGF-23 and bone metabolism
por: Kakareko, Katarzyna, et al.
Publicado: (2017)

FGF-23, Klotho and Vitamin D Levels in Scleroderma
por: AHMADI, Ravan, et al.
Publicado: (2017)

The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model
por: Spann, Redin A., et al.
Publicado: (2022)

Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function
por: Lindberg, Karolina, et al.
Publicado: (2013)

FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases
por: Tillman, Erik J., et al.
Publicado: (2020)

Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
por: Cheng, Peng, et al.
Publicado: (2016)

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability
por: An, Seong J., et al.
Publicado: (2023)

FGF19 and FGF21: In NASH we trust
por: Talukdar, Saswata, et al.
Publicado: (2020)

Paracrine Effects of FGF23 on the Heart
por: Leifheit-Nestler, Maren, et al.
Publicado: (2018)

The Association Between FGF21 and Diabetic Erectile Dysfunction: Evidence from Clinical and Animal Studies
por: Yang, Song, et al.
Publicado: (2022)

Is there a role in acute kidney injury for FGF23 and Klotho?
por: Mattinzoli, Deborah, et al.
Publicado: (2023)

Total serum FGF-21 levels positively relate to visceral adiposity differently from its functional intact form
por: Crudele, Lucilla, et al.
Publicado: (2023)

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
por: Adams, Andrew C., et al.
Publicado: (2012)

Close association between lifestyle and circulating FGF21 levels: A systematic review and meta-analysis
por: Qian, Zonghao, et al.
Publicado: (2022)

FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism
por: Szczepańska, Ewa, et al.
Publicado: (2022)

Analysis of Functional Promoter of Camel FGF21 Gene and Identification of Small Compounds Targeting FGF21 Protein
por: Yong, Fang, et al.
Publicado: (2023)

Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue
por: Klein Hazebroek, Marlou, et al.
Publicado: (2022)

Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism
por: Takeshita, Ai, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nebvomagpagjlmpur24u1h2c9f