Noncovalent antibody catenation on a target surface greatly increases the antigen-binding avidity

Immunoglobulin G (IgG) antibodies are widely used for diagnosis and therapy. Given the unique dimeric structure of IgG, we hypothesized that, by genetically fusing a homodimeric protein (catenator) to the C-terminus of IgG, reversible catenation of antibody molecules could be induced on a surface wh...

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Detalles Bibliográficos
Autores principales: Song, Jinyeop, Jeong, Bo-Seong, Kim, Seong-Woo, Im, Seong-Bin, Kim, Seonghoon, Lai, Chih-Jen, Cho, Wonki, Jung, Jae U, Ahn, Myung-Ju, Oh, Byung-Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229114/
https://www.ncbi.nlm.nih.gov/pubmed/37249578
http://dx.doi.org/10.7554/eLife.81646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229114/
https://www.ncbi.nlm.nih.gov/pubmed/37249578
http://dx.doi.org/10.7554/eLife.81646

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