Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

Oxygenation levels are a determinative factor in T cell function. Here, we describe how oxygen tensions sensed by mouse and human T cells at the moment of activation act to persistently modulate both differentiation and function. We found that in a protocol of CAR-T cell generation, 24 hr of low oxy...

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Detalles Bibliográficos
Autores principales: Cunha, Pedro P, Minogue, Eleanor, Krause, Lena CM, Hess, Rita M, Bargiela, David, Wadsworth, Brennan J, Barbieri, Laura, Brombach, Carolin, Foskolou, Iosifina P, Bogeski, Ivan, Velica, Pedro, Johnson, Randall S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229120/
https://www.ncbi.nlm.nih.gov/pubmed/37166103
http://dx.doi.org/10.7554/eLife.84280

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