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Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions
Our brain is continuously challenged by daily experiences. Thus, how to avoid systematic erasing of previously encoded memories? While it has been proposed that a dual-learning system with ‘slow’ learning in the cortex and ‘fast’ learning in the hippocampus could protect previous knowledge from inte...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229123/ https://www.ncbi.nlm.nih.gov/pubmed/37252780 http://dx.doi.org/10.7554/eLife.84911 |
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author | Navarro Lobato, Irene Aleman-Zapata, Adrian Samanta, Anumita Bogers, Milan Narayanan, Shekhar Rayan, Abdelrahman Alonso, Alejandra van der Meij, Jacqueline Khamassi, Mehdi Khan, Zafar U Genzel, Lisa |
author_facet | Navarro Lobato, Irene Aleman-Zapata, Adrian Samanta, Anumita Bogers, Milan Narayanan, Shekhar Rayan, Abdelrahman Alonso, Alejandra van der Meij, Jacqueline Khamassi, Mehdi Khan, Zafar U Genzel, Lisa |
author_sort | Navarro Lobato, Irene |
collection | PubMed |
description | Our brain is continuously challenged by daily experiences. Thus, how to avoid systematic erasing of previously encoded memories? While it has been proposed that a dual-learning system with ‘slow’ learning in the cortex and ‘fast’ learning in the hippocampus could protect previous knowledge from interference, this has never been observed in the living organism. Here, we report that increasing plasticity via the viral-induced overexpression of RGS14414 in the prelimbic cortex leads to better one-trial memory, but that this comes at the price of increased interference in semantic-like memory. Indeed, electrophysiological recordings showed that this manipulation also resulted in shorter NonREM-sleep bouts, smaller delta-waves and decreased neuronal firing rates. In contrast, hippocampal-cortical interactions in form of theta coherence during wake and REM-sleep as well as oscillatory coupling during NonREM-sleep were enhanced. Thus, we provide the first experimental evidence for the long-standing and unproven fundamental idea that high thresholds for plasticity in the cortex protect preexisting memories and modulating these thresholds affects both memory encoding and consolidation mechanisms. |
format | Online Article Text |
id | pubmed-10229123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-102291232023-05-31 Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions Navarro Lobato, Irene Aleman-Zapata, Adrian Samanta, Anumita Bogers, Milan Narayanan, Shekhar Rayan, Abdelrahman Alonso, Alejandra van der Meij, Jacqueline Khamassi, Mehdi Khan, Zafar U Genzel, Lisa eLife Neuroscience Our brain is continuously challenged by daily experiences. Thus, how to avoid systematic erasing of previously encoded memories? While it has been proposed that a dual-learning system with ‘slow’ learning in the cortex and ‘fast’ learning in the hippocampus could protect previous knowledge from interference, this has never been observed in the living organism. Here, we report that increasing plasticity via the viral-induced overexpression of RGS14414 in the prelimbic cortex leads to better one-trial memory, but that this comes at the price of increased interference in semantic-like memory. Indeed, electrophysiological recordings showed that this manipulation also resulted in shorter NonREM-sleep bouts, smaller delta-waves and decreased neuronal firing rates. In contrast, hippocampal-cortical interactions in form of theta coherence during wake and REM-sleep as well as oscillatory coupling during NonREM-sleep were enhanced. Thus, we provide the first experimental evidence for the long-standing and unproven fundamental idea that high thresholds for plasticity in the cortex protect preexisting memories and modulating these thresholds affects both memory encoding and consolidation mechanisms. eLife Sciences Publications, Ltd 2023-05-30 /pmc/articles/PMC10229123/ /pubmed/37252780 http://dx.doi.org/10.7554/eLife.84911 Text en © 2023, Navarro Lobato et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Navarro Lobato, Irene Aleman-Zapata, Adrian Samanta, Anumita Bogers, Milan Narayanan, Shekhar Rayan, Abdelrahman Alonso, Alejandra van der Meij, Jacqueline Khamassi, Mehdi Khan, Zafar U Genzel, Lisa Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions |
title | Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions |
title_full | Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions |
title_fullStr | Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions |
title_full_unstemmed | Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions |
title_short | Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions |
title_sort | increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229123/ https://www.ncbi.nlm.nih.gov/pubmed/37252780 http://dx.doi.org/10.7554/eLife.84911 |
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