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Self-organization of songbird neural sequences during social isolation

Behaviors emerge via a combination of experience and innate predispositions. As the brain matures, it undergoes major changes in cellular, network, and functional properties that can be due to sensory experience as well as developmental processes. In normal birdsong learning, neural sequences emerge...

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Autores principales: Mackevicius, Emily L, Gu, Shijie, Denisenko, Natalia I, Fee, Michale S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229124/
https://www.ncbi.nlm.nih.gov/pubmed/37252761
http://dx.doi.org/10.7554/eLife.77262
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author Mackevicius, Emily L
Gu, Shijie
Denisenko, Natalia I
Fee, Michale S
author_facet Mackevicius, Emily L
Gu, Shijie
Denisenko, Natalia I
Fee, Michale S
author_sort Mackevicius, Emily L
collection PubMed
description Behaviors emerge via a combination of experience and innate predispositions. As the brain matures, it undergoes major changes in cellular, network, and functional properties that can be due to sensory experience as well as developmental processes. In normal birdsong learning, neural sequences emerge to control song syllables learned from a tutor. Here, we disambiguate the role of tutor experience and development in neural sequence formation by delaying exposure to a tutor. Using functional calcium imaging, we observe neural sequences in the absence of tutoring, demonstrating that tutor experience is not necessary for the formation of sequences. However, after exposure to a tutor, pre-existing sequences can become tightly associated with new song syllables. Since we delayed tutoring, only half our birds learned new syllables following tutor exposure. The birds that failed to learn were the birds in which pre-tutoring neural sequences were most ‘crystallized,’ that is, already tightly associated with their (untutored) song.
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spelling pubmed-102291242023-05-31 Self-organization of songbird neural sequences during social isolation Mackevicius, Emily L Gu, Shijie Denisenko, Natalia I Fee, Michale S eLife Neuroscience Behaviors emerge via a combination of experience and innate predispositions. As the brain matures, it undergoes major changes in cellular, network, and functional properties that can be due to sensory experience as well as developmental processes. In normal birdsong learning, neural sequences emerge to control song syllables learned from a tutor. Here, we disambiguate the role of tutor experience and development in neural sequence formation by delaying exposure to a tutor. Using functional calcium imaging, we observe neural sequences in the absence of tutoring, demonstrating that tutor experience is not necessary for the formation of sequences. However, after exposure to a tutor, pre-existing sequences can become tightly associated with new song syllables. Since we delayed tutoring, only half our birds learned new syllables following tutor exposure. The birds that failed to learn were the birds in which pre-tutoring neural sequences were most ‘crystallized,’ that is, already tightly associated with their (untutored) song. eLife Sciences Publications, Ltd 2023-05-30 /pmc/articles/PMC10229124/ /pubmed/37252761 http://dx.doi.org/10.7554/eLife.77262 Text en © 2023, Mackevicius et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Mackevicius, Emily L
Gu, Shijie
Denisenko, Natalia I
Fee, Michale S
Self-organization of songbird neural sequences during social isolation
title Self-organization of songbird neural sequences during social isolation
title_full Self-organization of songbird neural sequences during social isolation
title_fullStr Self-organization of songbird neural sequences during social isolation
title_full_unstemmed Self-organization of songbird neural sequences during social isolation
title_short Self-organization of songbird neural sequences during social isolation
title_sort self-organization of songbird neural sequences during social isolation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229124/
https://www.ncbi.nlm.nih.gov/pubmed/37252761
http://dx.doi.org/10.7554/eLife.77262
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