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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR allosteric modulators remains limited. The M(4) mu...
Autores principales: | Vuckovic, Ziva, Wang, Jinan, Pham, Vi, Mobbs, Jesse I, Belousoff, Matthew J, Bhattarai, Apurba, Burger, Wessel AC, Thompson, Geoff, Yeasmin, Mahmuda, Nawaratne, Vindhya, Leach, Katie, van der Westhuizen, Emma T, Khajehali, Elham, Liang, Yi-Lynn, Glukhova, Alisa, Wootten, Denise, Lindsley, Craig W, Tobin, Andrew, Sexton, Patrick, Danev, Radostin, Valant, Celine, Miao, Yinglong, Christopoulos, Arthur, Thal, David M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229135/ https://www.ncbi.nlm.nih.gov/pubmed/37248726 http://dx.doi.org/10.7554/eLife.83477 |
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